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Review

The Intricate Interplay between Epigenetic Events, Alternative Splicing and Noncoding RNA Deregulation in Colorectal Cancer

1
Centre for Cancer Research and Cell Biology, Queen’s University Belfast, Belfast BT9 7AE, UK
2
Nastaran Center for Cancer Prevention (NCCP), Mashhad 9185765476, Iran
3
Stem Cells and Regenerative Medicine Research Group, Academic Center for Education, Culture Research (ACECR), Khorasan Razavi Branch, Mashhad 9177949367, Iran
4
Gene & Stem Cell Therapy Program Centenary Institute, The University of Sydney, Camperdown, NSW 2050, Australia
5
Sydney Medical School, The University of Sydney, Camperdown, NSW 2050, Australia
6
Computational BioMedicine Laboratory Centenary Institute, The University of Sydney, Camperdown, NSW 2050, Australia
*
Author to whom correspondence should be addressed.
Cells 2019, 8(8), 929; https://doi.org/10.3390/cells8080929
Received: 31 July 2019 / Revised: 16 August 2019 / Accepted: 16 August 2019 / Published: 19 August 2019
Colorectal cancer (CRC) results from a transformation of colonic epithelial cells into adenocarcinoma cells due to genetic and epigenetic instabilities, alongside remodelling of the surrounding stromal tumour microenvironment. Epithelial-specific epigenetic variations escorting this process include chromatin remodelling, histone modifications and aberrant DNA methylation, which influence gene expression, alternative splicing and function of non-coding RNA. In this review, we first highlight epigenetic modulators, modifiers and mediators in CRC, then we elaborate on causes and consequences of epigenetic alterations in CRC pathogenesis alongside an appraisal of the complex feedback mechanisms realized through alternative splicing and non-coding RNA regulation. An emphasis in our review is put on how this intricate network of epigenetic and post-transcriptional gene regulation evolves during the initiation, progression and metastasis formation in CRC. View Full-Text
Keywords: chromatin remodelling; histone modifications; aberrant DNA methylation; long non-coding RNA; microRNA chromatin remodelling; histone modifications; aberrant DNA methylation; long non-coding RNA; microRNA
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MDPI and ACS Style

Amirkhah, R.; Naderi-Meshkin, H.; Shah, J.S.; Dunne, P.D.; Schmitz, U. The Intricate Interplay between Epigenetic Events, Alternative Splicing and Noncoding RNA Deregulation in Colorectal Cancer. Cells 2019, 8, 929. https://doi.org/10.3390/cells8080929

AMA Style

Amirkhah R, Naderi-Meshkin H, Shah JS, Dunne PD, Schmitz U. The Intricate Interplay between Epigenetic Events, Alternative Splicing and Noncoding RNA Deregulation in Colorectal Cancer. Cells. 2019; 8(8):929. https://doi.org/10.3390/cells8080929

Chicago/Turabian Style

Amirkhah, Raheleh, Hojjat Naderi-Meshkin, Jaynish S. Shah, Philip D. Dunne, and Ulf Schmitz. 2019. "The Intricate Interplay between Epigenetic Events, Alternative Splicing and Noncoding RNA Deregulation in Colorectal Cancer" Cells 8, no. 8: 929. https://doi.org/10.3390/cells8080929

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