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PML Bodies in Mitosis

Oslo University Hospital, Department of Molecular Microbiology, Forskningsveien 1, 0373 Oslo, Norway
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Cells 2019, 8(8), 893; https://doi.org/10.3390/cells8080893
Received: 5 July 2019 / Revised: 8 August 2019 / Accepted: 10 August 2019 / Published: 14 August 2019
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Abstract

Promyelocytic leukemia (PML) bodies are dynamic intracellular structures that recruit and release a variety of different proteins in response to stress, virus infection, DNA damage and cell cycle progression. While PML bodies primarily are regarded as nuclear compartments, they are forced to travel to the cytoplasm each time a cell divides, due to breakdown of the nuclear membrane at entry into mitosis and subsequent nuclear exclusion of nuclear material at exit from mitosis. Here we review the biochemical and biophysical transitions that occur in PML bodies during mitosis and discuss this in light of post-mitotic nuclear import, cell fate decision and acute promyelocytic leukemia therapy. View Full-Text
Keywords: Promyelocytic leukemia protein; PML; PML bodies; APL; mitosis; nuclear import; nuclear bodies; liquid-liquid phase separation Promyelocytic leukemia protein; PML; PML bodies; APL; mitosis; nuclear import; nuclear bodies; liquid-liquid phase separation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Lång, A.; Lång, E.; Bøe, S.O. PML Bodies in Mitosis. Cells 2019, 8, 893.

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