Next Article in Journal
DROSHA-Dependent AIM2 Inflammasome Activation Contributes to Lung Inflammation during Idiopathic Pulmonary Fibrosis
Next Article in Special Issue
Hepatitis C Virus Improves Human Tregs Suppressive Function and Promotes Their Recruitment to the Liver
Previous Article in Journal
Leukocyte-Derived Extracellular Vesicles in Blood with and without EpCAM Enrichment
Review

Transcriptional Regulation of Differentiation and Functions of Effector T Regulatory Cells

Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University, 1919-1 Tancha, Onna-son, Okinawa 904-0495, Japan
*
Author to whom correspondence should be addressed.
Cells 2019, 8(8), 939; https://doi.org/10.3390/cells8080939
Received: 16 July 2019 / Revised: 10 August 2019 / Accepted: 15 August 2019 / Published: 20 August 2019
(This article belongs to the Special Issue Regulatory T (Treg) Cells in Health and Diseases)
Foxp3-expressing regulatory T (Treg) cells can suppress the activity of various types of immune cells and play key roles in the maintenance of self-tolerance and in the regulation of immune responses against pathogens and tumor cells. Treg cells consist of heterogeneous subsets that have distinct phenotypes and functions. Upon antigen stimulation, naïve-like thymus-derived Treg cells, which circulate in secondary lymphoid organs, can differentiate into effector Treg (eTreg) cells and migrate to and control immune homeostasis of peripheral tissues. eTreg cells are heterogeneous in terms of their ability to localize to specific tissues and suppress particular types of immune responses. Differentiation and function of diverse eTreg subsets are regulated by a variety of transcription factors that are activated by antigens and cytokines. In this article, we review the current understanding of the transcriptional regulation of differentiation and function of eTreg cells. View Full-Text
Keywords: Treg subsets; effector Treg; transcriptional regulation Treg subsets; effector Treg; transcriptional regulation
Show Figures

Figure 1

MDPI and ACS Style

Koizumi, S.-i.; Ishikawa, H. Transcriptional Regulation of Differentiation and Functions of Effector T Regulatory Cells. Cells 2019, 8, 939. https://doi.org/10.3390/cells8080939

AMA Style

Koizumi S-i, Ishikawa H. Transcriptional Regulation of Differentiation and Functions of Effector T Regulatory Cells. Cells. 2019; 8(8):939. https://doi.org/10.3390/cells8080939

Chicago/Turabian Style

Koizumi, Shin-ichi, and Hiroki Ishikawa. 2019. "Transcriptional Regulation of Differentiation and Functions of Effector T Regulatory Cells" Cells 8, no. 8: 939. https://doi.org/10.3390/cells8080939

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop