Special Issue "150 Years of Motor Endplate: Molecules, Cells, and Relevance of a Model Synapse"
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (30 June 2019).
2 Interdisciplinary Center for Neuroscience, Heidelberg University, Heidelberg, Germany
3 Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany
Interests: neuromuscular junction; 3D cell culture
Special Issues and Collections in MDPI journals
More than 150 years after the terms ‘plaques nerveuses terminales’ and ‘motorische Endplatte’ were coined by Charles Rouget and Wilhelm Krause, respectively, the neuromuscular synapse continues to be crucial for the musculoskeletal and neural sciences. Having always served as a model in terms of morphological and molecular configuration of chemical synapses, recent research has renewed an interest in the involvement of the motor endplate in general systemic functions of muscle beyond inducing contraction. Along these lines, the endplate has lately also attracted increasing attention with respect to its role in pathophysiology and aging.
This Special Issue of Cells will focus on the progress in understanding the molecular and cellular frameworks that regulate and mediate formation, maintenance, and repair of the motor endplate in normal physiology and upon pathological conditions. Further, it will address consequences of these insights on treatment of neuromuscular diseases and muscle wasting conditions.
Dr. Rüdiger Rudolf
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- neuromuscular synapse
- muscle innervation
- neuromuscular disorders
- muscle wasting
- muscle regeneration