Micromachines, Volume 16, Issue 11
2025 November - 112 articles
Cover Story: Cellular stiffness reflects intrinsic factors and environmental changes, suggesting its potential as a label-free disease biomarker. To investigate the mechanical contribution of intracellular structures by applying large deformations, we developed a microhand system. This system utilizes plate-shaped end-effectors to compress the cell, enabling accurate measurement using an integrated piezo actuator and a microforce sensor capable of nano-Newton (nN)-order force measurement. Consequently, we revealed that the single cell stiffness distribution of Hutchinson–Gilford progeria syndrome (HGPS) model cells significantly differed from that of control cells. View this paper
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Micromachines - ISSN 2072-666X