Emerging Devices and Technologies in BioMEMS for Biomarker Detection

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B1: Biosensors".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 568

Special Issue Editors


E-Mail Website
Guest Editor
School of Microelectronics, South China University of Technology, Guangzhou 510641, China
Interests: biosensors; BioMEMS; RF devices; microfluidics; acoustofluidics

E-Mail Website
Guest Editor
College of Mechanical Engineering, Guangxi University, Nanning 530004, China
Interests: mechanobiology; single-cell test; cellular biophysical properties; microfluidics; advanced biomedical methodologies
Pillar of Engineering Product Development, Singapore University of Technology and Design, 8 Somapah Road, Singapore 487372, Singapore
Interests: micro/nanofluidics technologies; BioMEMS; lab-on-a-chip; acoustofluidics; electrokinetics; single-cell analysis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recent advances in BioMEMS have led to the development of novel devices and integrated technologies specifically designed for the detection and analysis of biomarkers in body fluids. These biomarkers, including small molecules, proteins, nucleic acids, metabolites, extracellular vesicles, and cells such as circulating tumor cells and immune subsets, provide critical information for early diagnosis, disease monitoring, and therapeutic decision-making. Innovative BioMEMS platforms now feature enhanced microfluidic architectures, multifunctional sensing modules, and programmable control systems that enable precise, high-throughput, and label-free analysis using minimally invasive samples such as blood, saliva, sweat, and urine. Emerging trends include the integration of flexible electronics, hybrid field detection and manipulation (electrical, acoustic, or optical), and AI-assisted signal processing, all of which significantly improve sensitivity, specificity, and clinical utility. These technological innovations are accelerating the translation of BioMEMS into practical tools for point-of-care diagnostics and personalized medicine.

This Special Issue welcomes original research articles, communications, and reviews that highlight novel BioMEMS devices and technologies that enable circulating biomarker detection, with an emphasis on system design, detection mechanisms, analytical performance, and biomedical applications.

We look forward to receiving your contributions.

Dr. Jianwei Zhong
Dr. Minhui Liang
Dr. Ye Ai
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • micro/nanodevices
  • nanomaterials
  • device miniaturization
  • circulating biomarkers detection
  • assay technologies lab-on-chip
  • wearable electronics
  • point-of-care testing devices
  • AI-assisted processing

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

16 pages, 5289 KB  
Article
Non-Invasive Three-Dimensional Cell Manipulation Technology Based on Acoustic Microfluidic Chips
by Lin Lin, Yiming Zhen, Wang Li, Guoqiang Dong, Rongxing Zhu and Minhui Liang
Micromachines 2025, 16(9), 1068; https://doi.org/10.3390/mi16091068 - 22 Sep 2025
Viewed by 446
Abstract
This study presents a non-invasive three-dimensional cell manipulation technique based on acoustic microfluidic chips, which generates acoustic flow fields through the vibration of micropillars induced by bulk acoustic waves to achieve precise multi-dimensional rotational manipulation of cells. Moreover, the characteristics of the acoustic [...] Read more.
This study presents a non-invasive three-dimensional cell manipulation technique based on acoustic microfluidic chips, which generates acoustic flow fields through the vibration of micropillars induced by bulk acoustic waves to achieve precise multi-dimensional rotational manipulation of cells. Moreover, the characteristics of the acoustic flow field under linear, quasi-circular, elliptical, and higher-order vibration modes were intensively studied, and the rotational manipulation performance of polystyrene microbeads and cancer cells was optimized by adjusting the frequency and voltage. The results showed that the rotational speed and direction of the particles varied significantly in different vibration modes, with the particles and cells achieving the highest rotational speed in the elliptical vibration mode (frequency: 44.9 kHz, and voltage: 60 Vpp). In addition, the technique successfully achieved in-plane and out-of-plane rotation of cancer cells, and cell viability tests showed that 94% of the cells remained active after manipulation, demonstrating the low damage and biocompatibility of the method. This study provides a new, efficient, precise and gentle approach to three-dimensional manipulation of cells, which holds significant potential in biomedical research and clinical applications. Full article
(This article belongs to the Special Issue Emerging Devices and Technologies in BioMEMS for Biomarker Detection)
Show Figures

Figure 1

Back to TopTop