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Current Oncology, Volume 29, Issue 8

August 2022 - 63 articles

Cover Story: Immediate Lymphatic Reconstruction (ILR) is a promising technique to mitigate the risk of lymphedema in patients undergoing axillary (ALND) or inguinal (ILND) lymph node dissection (LND). This study was conducted to define lymphedema rates and risk factors in the context of melanoma. A retrospective chart review over 5 years identified 66 patients having undergone LND for melanoma (ALND 34, ILND 32). At a median follow-up of 29 months, 85.3% (n = 29) of patients having had an ALND did not experience lymphedema, versus 50.0% (n = 16) of ILND (p = 0.0019). On multivariate analysis, only the location of LND remained a significant predictor of lymphedema, with inguinal location identified as a potential first target for ILR. View this paper
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Articles (63)

  • Article
  • Open Access
20 Citations
4,780 Views
17 Pages

15 August 2022

Background: This study aims to evaluate the overall and breast cancer-specific survival (BCSS) after breast-conserving surgery (BCS) plus radiotherapy (RT) compared with mastectomy plus RT in resectable breast cancer. Moreover, the aim is to also ide...

  • Article
  • Open Access
1 Citations
2,912 Views
16 Pages

Detection of Potential Mutated Genes Associated with Common Immunotherapy Biomarkers in Non-Small-Cell Lung Cancer Patients

  • Lei Cao,
  • Zhili Cao,
  • Hongsheng Liu,
  • Naixin Liang,
  • Zhongxing Bing,
  • Caijuan Tian and
  • Shanqing Li

15 August 2022

Microsatellite instability (MSI), high tumor mutation burden (TMB-H) and programmed cell death 1 ligand 1 (PD-L1) expression are hot biomarkers related to the improvement of immunotherapy response. Two cohorts of non-small-cell lung cancer (NSCLC) we...

  • Article
  • Open Access
7 Citations
3,516 Views
13 Pages

Neoadjuvant Chemotherapy in Pregnant Patients with Cervical Cancer: A Monocentric Retrospective Study

  • Federica Bernardini,
  • Gabriella Ferrandina,
  • Caterina Ricci,
  • Anna Fagotti,
  • Francesco Fanfani,
  • Anna Franca Cavaliere,
  • Benedetta Gui,
  • Giovanni Scambia and
  • Rosa De Vincenzo

14 August 2022

Background: To date, little and discordant data still exists on the management of cervical cancer (CC) during pregnancy. In this paper, we report our experience of the treatment of these patients analyzing the oncologic, obstetric, and neonatal outco...

  • Article
  • Open Access
9 Citations
3,129 Views
16 Pages

Donor-Site Morbidity and Quality of Life after Autologous Breast Reconstruction with PAP versus TMG Flap

  • Angela Augustin,
  • Petra Pülzl,
  • Evi M. Morandi,
  • Selina Winkelmann,
  • Ines Schoberleitner,
  • Christine Brunner,
  • Magdalena Ritter,
  • Thomas Bauer,
  • Tanja Wachter and
  • Dolores Wolfram

11 August 2022

The transverse myocutaneous gracilis (TMG) and the profunda artery perforator (PAP) flap are both safe choices for autologous breast reconstruction originating from the same donor region in the upper thigh. We aimed to compare the post-operative outc...

  • Review
  • Open Access
5 Citations
5,976 Views
18 Pages

11 August 2022

Columnar cell lesions (CCLs) of the breast comprise a spectrum of morphologic alterations of the terminal duct lobular unit involving variably dilated and enlarged acini lined by columnar epithelial cells. The World Health Organization currently clas...

  • Article
  • Open Access
6 Citations
2,959 Views
9 Pages

11 August 2022

Background: The present study was conducted to define the lymphedema rate at our institution in patients undergoing axillary (ALND) or inguinal (ILND) lymph node dissection (LND) for melanoma. It aimed to examine risk factors predisposing patients to...

  • Commentary
  • Open Access
9 Citations
4,254 Views
11 Pages

9 August 2022

Quality medical practice is based on science and evidence. For over a half-century, the efficacy of breast cancer screening has been challenged, particularly for women aged 40–49. As each false claim has been raised, it has been addressed and r...

  • Article
  • Open Access
16 Citations
13,908 Views
17 Pages

The Impact of Organised Screening Programs on Breast Cancer Stage at Diagnosis for Canadian Women Aged 40–49 and 50–59

  • Anna N. Wilkinson,
  • Jean-Michel Billette,
  • Larry F. Ellison,
  • Michael A. Killip,
  • Nayaar Islam and
  • Jean M. Seely

9 August 2022

The relationship between Canadian mammography screening practices for women 40–49 and breast cancer (BC) stage at diagnosis in women 40–49 and 50–59 years was assessed using data from the Canadian Cancer Registry, provincial/territo...

  • Commentary
  • Open Access
3 Citations
2,833 Views
11 Pages

Engaging Patients in the Canadian Real-World Evidence for Value in Cancer Drugs (CanREValue) Initiative: Processes and Lessons Learned

  • William K. Evans,
  • Pam Takhar,
  • Valerie McDonald,
  • Martine Elias,
  • Louise Binder,
  • Stéphanie Michaud,
  • Mina Tadrous,
  • Caroline Muñoz and
  • Kelvin K. W. Chan

7 August 2022

The Canadian Real-world Evidence for Value in Cancer Drugs (CanREValue) Collaboration established the Engagement Working Group (WG) to ensure that all key stakeholders had an opportunity to provide input into the development and implementation of the...

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Curr. Oncol. - ISSN 1718-7729