Special Issue "Current State of Immunotherapy for Lung Cancer"

A special issue of Current Oncology (ISSN 1718-7729). This special issue belongs to the section "Thoracic Oncology".

Deadline for manuscript submissions: closed (30 September 2021).

Special Issue Editor

Prof. Dr. Barbara Melosky
E-Mail Website
Guest Editor
Department of Medical Oncology, The University of British Columbia, Vancouver, BC, Canada
Interests: NSCLC; targeted therapy; EGFR; Immunotherapy

Special Issue Information

Dear Colleagues,

New therapeutic agents continue to expand the use of immunotherapy in the lung cancer setting. The recent publication of influential trials has firmly placed immunotherapy as the standard of care for wild type non-small cell lung cancer (NSCLC) in the first and second line setting in advanced disease and following chemotherapy/radiation in stage lll NSCLC. We hope it soon will be the standard of care in mesothelioma. Evidence in efficacy exists in extensive stage small cell carcinoma and this will be reviewed.  

This Special Issue is aimed at all health care providers specializing in the care of patients with lung cancer. The issue provides a thorough summary of the most recent trial results for immunotherapy in the first line setting in advanced disease including trials KEYNOTE-189 and -407 and CheckMate 227 and 9LA. As we integrate immunotherapy into our clinical practice, we need to understand how to select the patients who are most likely to benefit from this therapy. Current and emerging biomarkers will be discussed. Supporting our patients through toxicity management is another practical matter we must consider, and is relevant to all jurisdictions, not just Canada.

Despite our enthusiasm for this treatment option, immunotherapy raises other important issues that need to be discussed, including improving efficacy, decreasing cost, expanding access and evaluating how immunotherapy works in a real world situation. We encourage all contributors, especially authors from other countries, to add their voice and perspectives to the current state of immunotherapy for lung cancer.

Prof. Dr. Barbara Melosky
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Oncology is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Review

Review
Immunotherapy in Extensive-Stage Small Cell Lung Cancer
Curr. Oncol. 2021, 28(5), 4093-4108; https://doi.org/10.3390/curroncol28050347 - 12 Oct 2021
Viewed by 414
Abstract
Small cell lung cancer (SCLC) remains a poorly understood disease with aggressive features, high relapse rates, and significant morbidity as well as mortality, yet persistently limited treatment options. For three decades, the treatment algorithm of SCLC has been stagnant despite multiple attempts to [...] Read more.
Small cell lung cancer (SCLC) remains a poorly understood disease with aggressive features, high relapse rates, and significant morbidity as well as mortality, yet persistently limited treatment options. For three decades, the treatment algorithm of SCLC has been stagnant despite multiple attempts to find alternative therapeutic options that could improve responses and increase survival rates. On the other hand, immunotherapy has been a thriving concept that revolutionized treatment options in multiple malignancies, rendering previously untreatable diseases potentially curable. In extensive stage SCLC, immunotherapy significantly altered the course of disease and is now part of the treatment algorithm in the first-line setting. Nevertheless, the important questions that arise are how best to implement immunotherapy, who would benefit the most, and finally, how to enhance responses. Full article
(This article belongs to the Special Issue Current State of Immunotherapy for Lung Cancer)
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