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Marine Drugs, Volume 19, Issue 11

November 2021 - 66 articles

Cover Story: The poor therapeutic response to glucocorticoid (GC) treatment is one of the challenges that the management of severe asthma faces. Compounds derived from marine sources have received increasing interest due to their potential for drug development. Based on the pathobiological features associated with GC resistance in severe asthma, many studies have previously described GC resistance mechanisms as potential therapeutic targets. Additionally, other studies have described the potential anti-inflammatory effects of marine-derived active compounds. This article compiles research regarding marine-derived compounds that target the pathogenic molecular mechanisms involved in GC-resistant asthma, and provides a basis for the development of effective marine-derived drugs.View this paper
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Articles (66)

  • Feature Paper
  • Article
  • Open Access
6 Citations
3,984 Views
15 Pages

Selection of Culture Conditions and Cell Morphology for Biocompatible Extraction of β-Carotene from Dunaliella salina

  • Guillaume Tanguy,
  • Aline Legat,
  • Olivier Gonçalves,
  • Luc Marchal and
  • Benoît Schoefs

22 November 2021

Biocompatible extraction emerges recently as a means to reduce costs of biotechnology processing of microalgae. In this frame, this study aimed at determining how specific culture conditions and the associated cell morphology impact the biocompatibil...

  • Review
  • Open Access
15 Citations
3,843 Views
17 Pages

Surface Glucan Structures in Aeromonas spp.

  • Elena Mendoza-Barberá,
  • Susana Merino and
  • Juan Tomás

22 November 2021

Aeromonas spp. are generally found in aquatic environments, although they have also been isolated from both fresh and processed food. These Gram-negative, rod-shaped bacteria are mostly infective to poikilothermic animals, although they are also cons...

  • Review
  • Open Access
24 Citations
9,255 Views
52 Pages

22 November 2021

This review focuses on a rare group of steroids and triterpenoids that share common properties as regulators of lipid metabolism. This group of compounds is divided by the type of chemical structure, and they represent: aromatic steroids, steroid pho...

  • Article
  • Open Access
8 Citations
3,134 Views
14 Pages

20 November 2021

Ovothiol is one of the most powerful antioxidants acting in marine organisms as a defense against oxidative stress during development and in response to environmental cues. The gene involved in the ovothiol biosynthesis, OvoA, is found in almost all...

  • Article
  • Open Access
6 Citations
3,108 Views
15 Pages

Complete Lipooligosaccharide Structure from Pseudoalteromonas nigrifaciens Sq02-Rifr and Study of Its Immunomodulatory Activity

  • Rossella Di Guida,
  • Angela Casillo,
  • Antonietta Stellavato,
  • Celeste Di Meo,
  • Soichiro Kawai,
  • Jun Kawamoto,
  • Takuya Ogawa,
  • Tatsuo Kurihara,
  • Chiara Schiraldi and
  • Maria Michela Corsaro

19 November 2021

Lipopolysaccharides (LPS) are surface glycoconjugates embedded in the external leaflet of the outer membrane (OM) of the Gram-negative bacteria. They consist of three regions: lipid A, core oligosaccharide (OS), and O-specific polysaccharide or O-ant...

  • Review
  • Open Access
42 Citations
4,840 Views
77 Pages

18 November 2021

The marine environment is an underexplored treasure that hosts huge biodiversity of microorganisms. Marine-derived fungi are a rich source of novel metabolites with unique structural features, bioactivities, and biotechnological applications. Marine-...

  • Article
  • Open Access
43 Citations
5,836 Views
14 Pages

Formulation, Optimization and In Vivo Evaluation of Fucoidan-Based Cream with Anti-Inflammatory Properties

  • Ekaterina D. Obluchinskaya,
  • Olga N. Pozharitskaya,
  • Elena V. Flisyuk and
  • Alexander N. Shikov

17 November 2021

Fucoidan is a polysaccharide found in brown alga with glorious potential for pharmacological activities, among which its anti-inflammatory properties have gained meaningful attention. Due to several advantages of formulations for topical application,...

  • Article
  • Open Access
13 Citations
5,047 Views
24 Pages

Deep-Water Fish Are Potential Vectors of Ciguatera Poisoning in the Gambier Islands, French Polynesia

  • Hélène Taiana Darius,
  • Taina Revel,
  • Philippe Cruchet,
  • Jérôme Viallon,
  • Clémence Mahana iti Gatti,
  • Manoëlla Sibat,
  • Philipp Hess and
  • Mireille Chinain

17 November 2021

Ciguatera poisoning (CP) cases linked to the consumption of deep-water fish occurred in 2003 in the Gambier Islands (French Polynesia). In 2004, on the request of two local fishermen, the presence of ciguatoxins (CTXs) was examined in part of their f...

  • Article
  • Open Access
3 Citations
3,446 Views
16 Pages

Probing the Therapeutic Potential of Marine Phyla by SPE Extraction

  • Alejandro Moreiras-Figueruelo,
  • Genoveffa Nuzzo,
  • Christian Galasso,
  • Clementina Sansone,
  • Fabio Crocetta,
  • Valerio Mazzella,
  • Carmela Gallo,
  • Giusi Barra,
  • Angela Sardo and
  • Antonella Iuliano
  • + 6 authors

16 November 2021

The marine environment is potentially a prolific source of small molecules with significant biological activities. In recent years, the development of new chromatographic phases and the progress in cell and molecular techniques have facilitated the s...

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Mar. Drugs - ISSN 1660-3397Creative Common CC BY license