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Marine Drugs
Special Issues
Marine Products with Anti-allergic and Anti-inflammatory Activities
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Marine Products with Anti-allergic and Anti-inflammatory Activities

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (30 December 2021) | Viewed by 22186

Special Issue Editors

Dr. K. K. Asanka Sanjeewa

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Guest Editor
Department of Biosystem technology, Faculty of Technology, University of Sri Jayewardenepura, Sri Lanka
Interests: anti-inflammation; antioxidant; fine dust; seaweeds
Special Issues, Collections and Topics in MDPI journals
Dr. Ilekuttige Priyan Shanura Fernando

E-Mail Website
Guest Editor
Department of Marine Bio-Food Sciences, Chonnam National University, Gwangju, Korea
Interests: marine natural products; medicinal chemistry; bioprospecting
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Marine resource bioprospecting has recently received considerable attention due to its potential industrial and agroeconomical value. The intriguing structural complexity and bioactivities of the secondary metabolites of marine organisms, coupled with their biocompatibility, allows for their potential use in the pharmaceutical, functional food, and cosmetic sectors. Active compounds in marine organisms are often reported to possess anti-inflammatory and anti-allergic properties under in vitro and in vivo conditions. Therefore, functional foods based on marine resources can enhance immunity and have a greater effect on disease control and prevention. The chemical characterization of extracts/remedies of marine resources and the study of signaling mechanisms underlying anti-inflammatory and anti-allergic activities will influence future developments in marine bioproduct industries.

The Marine Drugs Special Issue “Marine Products with Anti-Allergic and Anti-Inflammatory Activities” will publish a collection of articles on bioactive compounds derived from marine bioresources with anti-allergic and anti-inflammatory activities. This Special Issue welcomes high-quality studies conducted using multidisciplinary in vitro, in vivo, and in silico approaches aimed at identifying the anti-inflammatory and anti-allergic bioactives of marine organisms and their key mediatory mechanisms, potentially contributing to future developments in the seaweed industry.

Dr. K. K. Asanka Sanjeewa
Dr. I. P. Shanura Fernando
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine natural products
  • anti-inflammatory
  • anti-allergic
  • functional foods
  • phlorotannins
  • terpenoids
  • alkaloids
  • sulfated polysaccharides

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Published Papers (6 papers)

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Research

15 pages, 3603 KiB  
Article
Sargachromenol Isolated from Sargassum horneri Inhibits Particulate Matter-Induced Inflammation in Macrophages through Toll-like Receptor-Mediated Cell Signaling Pathways
by D. P. Nagahawatta, Hyun-Soo Kim, Young-Heun Jee, Thilina U. Jayawardena, Ginnae Ahn, Jin Namgung, In-Kyu Yeo, K. K. Asanka Sanjeewa and You-Jin Jeon
Mar. Drugs 2022, 20(1), 28; https://doi.org/10.3390/md20010028 - 24 Dec 2021
Cited by 8 | Viewed by 3429
Abstract
Sargassum horneri is an invasive brown seaweed that grows along the shallow coastal areas of the Korean peninsula, which are potentially harmful to fisheries and natural habitats in the areas where it is accumulated. Therefore, the author attempted to evaluate the anti-inflammatory mechanism [...] Read more.
Sargassum horneri is an invasive brown seaweed that grows along the shallow coastal areas of the Korean peninsula, which are potentially harmful to fisheries and natural habitats in the areas where it is accumulated. Therefore, the author attempted to evaluate the anti-inflammatory mechanism of Sargachromenol isolated from S. horneri against particulate matter (PM)-stimulated RAW 264.7 macrophages. PM is a potent inducer of respiratory diseases such as lung dysfunctions and cancers. In the present study, the anti-inflammatory properties of Sargachromenol were validated using enzyme-linked immunosorbent assay (ELISA), Western blots, and RT-qPCR experiments. According to the results, Sargachromenol significantly downregulated the PM-induced proinflammatory cytokines, Prostaglandin E2 (PGE2), and Nitric Oxide (NO) secretion via blocking downstream activation of Toll-like receptor (TLR)-mediated nuclear factor kappa B (NF-κB) and MAPKs phosphorylation. Thus, Sargachromenol is a potential candidate for innovation in various fields including pharmaceuticals, cosmeceuticals, and functional food. Full article
(This article belongs to the Special Issue Marine Products with Anti-allergic and Anti-inflammatory Activities)
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13 pages, 1715 KiB  
Article
Anti-Allergic Effect of Low Molecular Weight Digest from Abalone Viscera on Atopic Dermatitis-Induced NC/Nga
by Tae-Hee Kim, Seong-Yeong Heo, Gun-Woo Oh, Won Sun Park, Il-Whan Choi, Zhong-Ji Qian and Won-Kyo Jung
Mar. Drugs 2021, 19(11), 634; https://doi.org/10.3390/md19110634 - 12 Nov 2021
Cited by 4 | Viewed by 2917
Abstract
Abalone viscera (AV) is one of the byproducts of the seafood processing industry. The low molecular weight (<5 kDa) peptides (LMW-AV) obtained from gastrointestinal digestion of AV could suppress allergenic responses on activated HMC-1 human mast cells in our previous study. Regarding the [...] Read more.
Abalone viscera (AV) is one of the byproducts of the seafood processing industry. The low molecular weight (<5 kDa) peptides (LMW-AV) obtained from gastrointestinal digestion of AV could suppress allergenic responses on activated HMC-1 human mast cells in our previous study. Regarding the allergenic response of LMW-AV, in the present study, we further investigated the potential of oral administration of LMW-AV against atopic dermatitis (AD) in a dermatitis-induced model stimulated with Dermatophagoides farinae. The results demonstrated that the LMW-AV reduced a number of clinical symptoms, such as the severity of the dermatitis and serum immunoglobulin E levels. Moreover, LMW-AV could inhibit the expression of chemokines and cytokines. The histological analysis indicated that the LMW-AV has suppressed the eosinophil count and the mast cell infiltration into the upper dermis. The results suggest that LMW-AV can be considered as a promising candidate for AD treatment. Full article
(This article belongs to the Special Issue Marine Products with Anti-allergic and Anti-inflammatory Activities)
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10 pages, 2239 KiB  
Article
Sargachromenol Purified from Sargassum horneri Inhibits Inflammatory Responses via Activation of Nrf2/HO-1 Signaling in LPS-Stimulated Macrophages
by Eui-Jeong Han, Thilina U. Jayawardena, Jae-Hyuk Jang, Ilekuttige Priyan Shanura Fernando, Youngheun Jee, You-Jin Jeon, Dae-Sung Lee, Jeong-Min Lee, Mi-Jin Yim, Lei Wang, Hyun-Soo Kim and Ginnae Ahn
Mar. Drugs 2021, 19(9), 497; https://doi.org/10.3390/md19090497 - 31 Aug 2021
Cited by 12 | Viewed by 3174
Abstract
In this study, we isolated sargachromenol (SC) from Sargassum horneri and evaluated its anti-inflammatory effect in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. SC did not show cytotoxicity at all concentrations and effectively increased the cell viability by reducing the nitric oxide (NO) and intracellular [...] Read more.
In this study, we isolated sargachromenol (SC) from Sargassum horneri and evaluated its anti-inflammatory effect in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. SC did not show cytotoxicity at all concentrations and effectively increased the cell viability by reducing the nitric oxide (NO) and intracellular reactive oxygen species (ROS) production in LPS-stimulated RAW 264.7 macrophages. In addition, SC decreased the mRNA expression levels of inflammatory cytokines (IL-1β, IL-6, and TNF-α) and inflammatory mediators (iNOS and COX-2). Moreover, SC suppressed the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) and mitogen-activated protein kinase (MAPK) signaling, whereas activated the nuclear factor erythroid 2-related factor 2/heme oxygenase-1 (Nrf2/HO-1) signaling in LPS-stimulated RAW 264.7 macrophages. Interestingly, the anti-inflammatory effect of SC was abolished by the inhibition of HO-1 in LPS-stimulated RAW 264.7 macrophages. According to the results, this study suggests that the antioxidant capacity of SC leads to its anti-inflammatory effect and it potentially may be utilized in the nutraceutical and pharmaceutical sectors. Full article
(This article belongs to the Special Issue Marine Products with Anti-allergic and Anti-inflammatory Activities)
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14 pages, 5001 KiB  
Article
(−)-Loliolide Isolated from Sargassum horneri Abate UVB-Induced Oxidative Damage in Human Dermal Fibroblasts and Subside ECM Degradation
by Ilekuttige Priyan Shanura Fernando, Soo-Jin Heo, Mawalle Kankanamge Hasitha Madhawa Dias, Dissanayaka Mudiyanselage Dinesh Madusanka, Eui-Jeong Han, Min-Ju Kim, Kalu Kapuge Asanka Sanjeewa, Kyounghoon Lee and Ginnae Ahn
Mar. Drugs 2021, 19(8), 435; https://doi.org/10.3390/md19080435 - 30 Jul 2021
Cited by 14 | Viewed by 3709
Abstract
Ultraviolet (UV) B exposure is a prominent cause of skin aging and a contemporary subject of interest. The effects are progressing through the generation of reactive oxygen species (ROS) that alter cell signaling pathways related to inflammatory responses. The present study evaluates the [...] Read more.
Ultraviolet (UV) B exposure is a prominent cause of skin aging and a contemporary subject of interest. The effects are progressing through the generation of reactive oxygen species (ROS) that alter cell signaling pathways related to inflammatory responses. The present study evaluates the protective effects of (7aR)-6-hydroxy-4,4,7a-trimethyl-6,7-dihydro-5H-1-benzofuran-2-one (HTT) isolated from the edible brown algae Sargassum horneri against UVB protective effects in human dermal fibroblasts (HDFs). HTT treatment dose-dependently suppressed intracellular ROS generation in HDFs with an IC50 of 62.43 ± 3.22 µM. HTT abated UVB-induced mitochondrial hyperpolarization and apoptotic body formation. Furthermore, UVB-induced activation of key nuclear factor (NF)-κB and mitogen-activated protein kinase signaling proteins were suppressed in HTT treated cells while downregulating pro-inflammatory cytokines (interleukin-1β, 6, 8, 33 and tumor necrosis factor-α). Moreover, HTT treatment downregulated matrix metalloproteinase1, 2, 3, 8, 9 and 13 that was further confirmed by the inhibition of collagenase and elastase activity. The evidence implies that HTT delivers protective effects against premature skin aging caused by UVB exposure via suppressing inflammatory responses and degradation of extracellular matrix (ECM) components. Extensive research in this regard will raise perspectives for using HTT as an ingredient in UV protective ointments. Full article
(This article belongs to the Special Issue Marine Products with Anti-allergic and Anti-inflammatory Activities)
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20 pages, 3182 KiB  
Article
Anti-Inflammatory Effects of Sulfated Polysaccharide from Sargassum swartzii in Macrophages via Blocking TLR/NF-Κb Signal Transduction
by Thilina U. Jayawardena, K. K. Asanka Sanjeewa, D. P. Nagahawatta, Hyo-Geun Lee, Yu-An Lu, A. P. J. P. Vaas, D. T. U. Abeytunga, C. M. Nanayakkara, Dae-Sung Lee and You-Jin Jeon
Mar. Drugs 2020, 18(12), 601; https://doi.org/10.3390/md18120601 - 28 Nov 2020
Cited by 48 | Viewed by 4546
Abstract
This study involves enzymatic extraction of fucoidan from Sargassum swartzii and further purification via ion-exchange chromatography. The chemical and molecular characteristics of isolated fucoidan is evaluated concerning its anti-inflammatory potential in RAW 264.7 macrophages under LPS induced conditions. Structural properties of fucoidan were [...] Read more.
This study involves enzymatic extraction of fucoidan from Sargassum swartzii and further purification via ion-exchange chromatography. The chemical and molecular characteristics of isolated fucoidan is evaluated concerning its anti-inflammatory potential in RAW 264.7 macrophages under LPS induced conditions. Structural properties of fucoidan were assessed via FTIR and NMR spectroscopy. NO production stimulated by LPS was significantly declined by fucoidan. This was witnessed to be achieved via fucoidan acting on mediators such as iNOS and COX-2 including pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β), with dose dependent down-regulation. Further, the effect is exhibited by the suppression of TLR mediated MyD88, IKK complex, ultimately hindering NF-κB and MAPK activation, proposing its therapeutic applications in inflammation related disorders. The research findings provide an insight in relation to the sustainable utilization of fucoidan from marine brown algae S. swartzii as a potent anti-inflammatory agent in the nutritional, pharmaceutical, and cosmeceutical sectors. Full article
(This article belongs to the Special Issue Marine Products with Anti-allergic and Anti-inflammatory Activities)
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12 pages, 2725 KiB  
Article
Sargassum horneri as a Functional Food Ameliorated IgE/BSA-Induced Mast Cell Activation and Passive Cutaneous Anaphylaxis in Mice
by Eui Jeong Han, Hyun-Soo Kim, Kalu Kapuge Asanka Sanjeewa, Kyungsook Jung, Youngheun Jee, You-Jin Jeon, Ilekuttige Priyan Shanura Fernando and Ginnae Ahn
Mar. Drugs 2020, 18(12), 594; https://doi.org/10.3390/md18120594 - 26 Nov 2020
Cited by 14 | Viewed by 3626
Abstract
Sargassum horneri (S. horneri), an edible brown alga, has been proposed as a functional food with an improvement effect on abnormal skin immune responses. The present study investigates the anti-allergic effect of an ethanol extract from S. horneri (SHE) on immunoglobulin [...] Read more.
Sargassum horneri (S. horneri), an edible brown alga, has been proposed as a functional food with an improvement effect on abnormal skin immune responses. The present study investigates the anti-allergic effect of an ethanol extract from S. horneri (SHE) on immunoglobulin E (IgE)/bovine serum albumin (BSA)-mediated activation in bone marrow-derived cultured-mast cells (BMCMCs) and passive cutaneous anaphylaxis (PCA) reaction in mice. SHE markedly and dose-dependently suppressed the degranulation of BMCMCs by reducing the β-hexosaminidase and histamine release without cytotoxicity. In addition, SHE significantly decreased the FcεRI expression on the surface of BMCMCs and its IgE binding. Moreover, SHE reduced the mRNA expression and the production of allergic cytokines; interleukin (IL)-1β, IL-4, IL-5, IL-6, IL-10, IL-13; interferon (IFN)-γ and/or tumor necrosis factor (TNF)-α; and a chemokine, thymus and activation-regulated chemokine (TARC), by suppressing the activation of Src-family kinases and nuclear factor (NF)-κB signaling. In further study, the application of SHE reduced the PCA reaction in an IgE/BSA-induced type I allergic mice model. Taken together, we suggest that SHE has an anti-allergic effect in type I allergic responses. Full article
(This article belongs to the Special Issue Marine Products with Anti-allergic and Anti-inflammatory Activities)
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