Special Issue "Carbohydrate-Containing Marine Compounds of Mixed Biogenesis"

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: 27 February 2021.

Special Issue Editors

Prof. Dr. Valentin A. Stonik
Website
Guest Editor
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 159 Prospect 100-let Vladivostoku, Vladivostok 690022, Russia
Interests: marine natural product chemistry; secondary metabolites; marine invertebrates; glycoconjugates; steroids; terpenoids; uncommon glycolipds; biochemistry; cell biology; pharmacology
Special Issues and Collections in MDPI journals
Dr. Natalia V. Ivanchina
Website
Guest Editor
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 159 Prospect 100-let Vladivostoku, Vladivostok 690022, Russia
Interests: marine natural product chemistry; secondary metabolites; starfish polyhydroxysteroids and their glycoconjugates; biological activities; metabolomics; biosynthesis Portrait
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Researchers studying secondary metabolites typically classify these compounds into isoprenoids, polyketides, peptides, shikimate derivatives, etc., taking into account their biogenetic origin. However, there are many other classes of natural compounds derived by mixed biogenesis, including combinations of the acetate-malonate, acetate-mevalonate, shikimic acid, and other biosynthetic pathways. Although the biosynthesis of such compounds requires additional metabolic energy, they usually lead to metabolites with high physiological and/or environmental activities. Organisms living in aquatic—including marine—environments often produce water-soluble natural compounds that embody carbohydrate fragments as their hydrophilic components. Glycoconjugates of this type are widely represented in diverse marine organisms. These include steroid and terpenoid glycosides, a variety of glycolipids, lipopoly- and lipooligosaccharides, glycosides of polyphenolic metabolites, glycosylated peptides and polyketides, and many other structural groups of marine natural compounds.

Recently, we were operating as Editors of the Special Issue “Marine Glycoconjugates” (https://www.mdpi.com/journal/marinedrugs/special_issues/Marine_Glycoconjugates_Trends_Perspectives), but in this generally successful Issue, there were no articles on many of the above-mentioned groups of marine metabolites. In accordance with invitation and sponsor support of the international scientific journal Marine Drugs, we have decided to continue this work. As a result, a Special Issue of this journal “Carbohydrate-Containing Marine Compounds of Mixed Biogenesis” will be prepared.

Prof. Dr. Valentin A. Stonik
Dr. Natalia V. Ivanchina
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine secondary metabolites
  • marine glycoconjugates
  • drug discovery
  • steroid and terpenoid marine glycosides
  • lipopoly- and oligoglycosides
  • glycolipids
  • structures
  • syntheses
  • biological activities

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Open AccessArticle
Structure and In Vitro Bioactivity against Cancer Cells of the Capsular Polysaccharide from the Marine Bacterium Psychrobacter marincola
Mar. Drugs 2020, 18(5), 268; https://doi.org/10.3390/md18050268 - 19 May 2020
Abstract
Psychrobacter marincola KMM 277T is a psychrophilic Gram-negative bacterium that has been isolated from the internal tissues of an ascidian Polysyncraton sp. Here, we report the structure of the capsular polysaccharide from P. marincola KMM 277T and its effect on the [...] Read more.
Psychrobacter marincola KMM 277T is a psychrophilic Gram-negative bacterium that has been isolated from the internal tissues of an ascidian Polysyncraton sp. Here, we report the structure of the capsular polysaccharide from P. marincola KMM 277T and its effect on the viability and colony formation of human acute promyelocytic leukemia HL-60 cells. The polymer was purified by several separation methods, including ultracentrifugation and chromatographic procedures, and the structure was elucidated by means of chemical analysis, 1-D, and 2-D NMR spectroscopy techniques. It was found that the polysaccharide consists of branched hexasaccharide repeating units containing two 2-N-acetyl-2-deoxy-d-galacturonic acids, and one of each of 2-N-acetyl-2-deoxy-d-glucose, d-glucose, d-ribose, and 7-N-acetylamino-3,5,7,9-tetradeoxy-5-N-[(R)-2-hydroxypropanoylamino]- l-glycero-l-manno-non-2-ulosonic acid. To our knowledge, this is the first finding a pseudaminic acid decorated with lactic acid residue in polysaccharides. The biological analysis showed that the capsular polysaccharide significantly reduced the viability and colony formation of HL-60 cells. Taken together, our data indicate that the capsular polysaccharide from P. marincola KMM 277T is a promising substance for the study of its antitumor properties and the mechanism of action in the future. Full article
(This article belongs to the Special Issue Carbohydrate-Containing Marine Compounds of Mixed Biogenesis)
Show Figures

Figure 1

Back to TopTop