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International Journal of Molecular Sciences, Volume 26, Issue 11

June-1 2025 - 464 articles

Cover Story: Helicobacter pylori is a human gastric pathogen whose persistence relies on stress response mechanisms, notably those mediated by heat shock proteins (HSPs). These chaperones aid in protein folding, immune evasion, and biofilm formation, supporting survival under acidic and oxidative stress. Key players like GroEL and DnaK exhibit dual roles in intracellular proteostasis and host interaction. Recent evidence highlights their involvement in the crosstalk between H. pylori and gastric epithelial cells mediated by the release of bacterial outer membrane vesicles and host-derived exosomes, with both extracellular vesicles being part of the muco-microbiotic layer of the stomach and influencing cellular signaling and immune modulation. These insights reveal novel therapeutic and vaccine targets. View this paper
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Articles (464)

  • Article
  • Open Access
1 Citations
1,051 Views
11 Pages

Purification of Prudu6 from Almond and Its Cross-Reactivity with Glym6 from Soybean

  • Changbao Hu,
  • Qishu Luo,
  • Lihua Zhou,
  • Weichao Zhu,
  • Kuan Gao,
  • Qin Geng,
  • Xin Li,
  • Anshu Yang,
  • Ping Tong and
  • Zhihua Wu
  • + 1 author

Almond (Prunus dulcis) is a tree nut with high nutritional value that is widely cultivated and consumed globally. Prudu6, an 11S globulin, is one of the main allergens in almond, which can trigger a series of severe allergic reactions. To our knowled...

  • Article
  • Open Access
888 Views
24 Pages

The demand for polymer composite materials in the dental market is increasing every year. This rise is due to their excellent properties and ongoing technological advancements. The goal of this study was to develop new photoinitiators included in the...

  • Brief Report
  • Open Access
1 Citations
1,565 Views
14 Pages

Brief Weekly Magnetic Field Exposure Enhances Avian Oxidative Muscle Character During Embryonic Development

  • Jasmine Lye Yee Yap,
  • Kwan Yu Wu,
  • Yee Kit Tai,
  • Charlene Hui Hua Fong,
  • Neha Manazir,
  • Anisha Praiselin Paul,
  • Olivia Yeo and
  • Alfredo Franco-Obregón

Maternal metabolic dysfunction adversely influences embryonic muscle oxidative capacity and mitochondrial biogenesis, increasing the child’s long-term risks of developing obesity and metabolic syndrome in later life. This pilot study explored t...

  • Article
  • Open Access
1,772 Views
24 Pages

Chronic inflammatory pain (IP) remains a therapeutic challenge under the worldwide prevalence of the high-fat dietary lifestyle. This study aimed at identifying mediators of the IP augmented by short-term high-fat diet (HFD). IP was induced on C57BL/...

  • Review
  • Open Access
2 Citations
3,739 Views
15 Pages

Osseointegration is the direct contact between living bone and a dental implant, with supporting evidence confirming the direct connection between bone and titanium, found using an electron microscope. However, the fundamental mechanisms and intercon...

  • Communication
  • Open Access
1 Citations
1,249 Views
12 Pages

Spherified Pd0.33Ni0.67/BCNT Catalyst for Nitrobenzene Hydrogenation

  • Csenge Nagy,
  • Emőke Sikora,
  • Ádám Prekob,
  • Kitti Gráczer,
  • Gábor Muránszky,
  • László Vanyorek,
  • Ferenc Kristály and
  • Zsolt Fejes

A separable bamboo-like carbon nanotube-based catalyst was prepared by the spherfication method using sodium alginate and nickel. The spheres were carbonized and then decorated with palladium nanoparticles before they were tested in nitrobenzene hydr...

  • Article
  • Open Access
1,486 Views
17 Pages

Anti-Inflammatory Potential of Essential Oil from the Heart-Wood of the Folk Medicinal Tree Cinnamomum kanehirai Hayata in Macrophages

  • May-Lan Liu,
  • Pang-Yen Liu,
  • Louis Kuoping Chao,
  • Tzu-Jung Yang,
  • Lan-Hui Li,
  • Yih-Ming Weng,
  • Sarana Rose Sommano,
  • Yuwalee Unpaprom,
  • Rameshprabu Ramaraj and
  • Chen-Lung Ho
  • + 1 author

Inflammation is a vital physiological response that plays a crucial role in regulating host defense against pathogens while maintaining tissue homeostasis. Inflammasomes, a family of protein complexes, are responsible for controlling the expression o...

  • Communication
  • Open Access
1,944 Views
11 Pages

Ursolic Acid-Based Nutraceutical Mitigates Muscle Atrophy and Improves Exercise Performance in Mouse Model of Peripheral Neuropathy

  • Caterina Miro,
  • Fortuna Iannuzzo,
  • Lucia Acampora,
  • Annunziata Gaetana Cicatiello,
  • Serena Sagliocchi,
  • Elisabetta Schiano,
  • Annarita Nappi,
  • Federica Restolfer,
  • Mariano Stornaiuolo and
  • Gian Carlo Tenore
  • + 2 authors

Peripheral nerve injuries, caused by trauma or iatrogenic damage, often lead to permanent disabilities with limited effectiveness of current therapeutic treatments. This has driven the growing interest toward natural bioactive molecules, including ur...

  • Review
  • Open Access
2 Citations
5,939 Views
26 Pages

Molecular Basis of Anxiety: A Comprehensive Review of 2014–2024 Clinical and Preclinical Studies

  • Ermis Merkouris,
  • Alexandra Brasinika,
  • Meropi Patsiavoura,
  • Chrysanthi Siniosoglou,
  • Dimitrios Tsiptsios,
  • Andreas S. Triantafyllis,
  • Christoph Mueller,
  • Ioulia Mpikou,
  • Myrto T. Samara and
  • Nikolaos Christodoulou
  • + 1 author

Anxiety disorders are among the most common psychiatric conditions that significantly impair one’s quality of life and place a significant burden on healthcare systems. Conventional treatments have certain restraints, such as potential side eff...

  • Review
  • Open Access
1 Citations
1,923 Views
26 Pages

The Role of the AGPAT2 Gene in Adipose Tissue Biology and Congenital Generalized Lipodystrophy Pathophysiology

  • Maria Eduarda Cardoso de Melo,
  • Letícia Marques Gomes da Silva,
  • Ana Carolina Costa Cavalcante,
  • Josivan Gomes Lima and
  • Julliane Tamara Araújo de Melo Campos

1-Acylglycerol-3-phosphate O-acyltransferase (1-AGPAT) is an enzyme family composed of 11 isoforms. Notably, 1-AGPAT 2, the most studied isoform since its discovery, is a critical enzyme in the triglyceride synthesis pathway, converting lysophosphati...

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Int. J. Mol. Sci. - ISSN 1422-0067