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Eye Diseases: From Pathophysiology to Novel Therapeutic Approaches

Special Issue Editors


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Guest Editor
Department of General Ophthalmology, Medical University of Lublin, ul. Chmielna 1, 20-079 Lublin, Poland
Interests: cataracts; corneal pathology and treatment; eye traumatology; neuroprotection
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of General and Pediatric Ophthalmology, Medical University of Lublin, 20-093 Lublin, Poland
Interests: eye diseases; cataract
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The progress made in clinical and experimental ophthalmology in recent years is remarkable. It would not be possible without developments in our progressively better understanding of the pathophysiology of eye diseases. New medicines and therapeutic strategies which have been introduced and implemented into everyday clinical practice are consequences of the work of laboratory experiments and observations on genetic, biochemical, proteomic, cellular, and physiological levels. In this Special Issue, entitled "Eye Diseases: From Pathophysiology to Novel Therapeutic Approaches", we welcome authors to submit papers that highlight new achievements in these fields. We encourage submissions focused on the molecular mechanisms underlying eye diseases and innovative therapeutic approaches, rooted in molecular research. We hope that improving our knowledge and outlining the most recent achievements in molecular insights brings new therapeutic possibilities to help rescue vision and inspires our readers and scientists by the new discoveries in both experimental and clinical ophthalmology.

Dr. Tomasz Chorągiewicz
Dr. Joanna Dolar-Szczasny
Guest Editors

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Keywords

  • eye diseases
  • genetic
  • biochemical
  • proteomic
  • cellular and physiological level
  • innovative therapeutic approaches

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Published Papers (1 paper)

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21 pages, 1040 KiB  
Review
Changes in the Protein Composition of the Aqueous Humor in Patients with Glaucoma: An Update Review
by Maria Kiełbus, Dominika Kuźmiuk, Aleksandra Magdalena Skrzyniarz, Aleksandra Zynkowska, Joanna Dolar-Szczasny, Tomasz Chorągiewicz and Robert Rejdak
Int. J. Mol. Sci. 2025, 26(7), 3129; https://doi.org/10.3390/ijms26073129 - 28 Mar 2025
Viewed by 424
Abstract
The study of the aqueous humor (AH) plays a key role in understanding the pathophysiology of glaucoma. The AH provides nutrition, maintains the appropriate intraocular pressure, and provides important information about the mechanisms of the disease. The development of modern technologies has allowed [...] Read more.
The study of the aqueous humor (AH) plays a key role in understanding the pathophysiology of glaucoma. The AH provides nutrition, maintains the appropriate intraocular pressure, and provides important information about the mechanisms of the disease. The development of modern technologies has allowed the use of more accurate analytical methods, which has proven to be a key factor in determining the changes occurring in the proteome of the aqueous humor of glaucoma patients. Recently, researchers have observed changes in the levels of proteins associated with inflammation, oxidative stress, the complement system, and extracellular matrix remodeling. They have also shown that these changes may be variable for different types of glaucoma. The objective of this review is to collect and summarize the current knowledge on the potential biomarkers and pathomechanisms involved in the pathogenesis of glaucoma. We hope that our review will contribute to the improvement of current diagnostic methods in this illness and, through a better understanding of the changes occurring during the progression of the disease, will enable the development of more effective preventive and therapeutic strategies in the future. Full article
(This article belongs to the Special Issue Eye Diseases: From Pathophysiology to Novel Therapeutic Approaches)
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