Basic Mechanisms of Physiological and Pathological Autoimmunity and Their Role in the Development of Autoimmune Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 20 November 2025 | Viewed by 4155
Special Issue Editor
Special Issue Information
Dear Colleagues,
We are pleased to announce the commencement of a Special Issue focusing on the significant topic of autoimmune research. Understanding the intricate relationship between physiological and pathological autoimmunity is paramount in elucidating the complexities inherent in the development of autoimmune diseases.
Over the past decades, extensive research has been conducted on physiological/natural and pathological autoimmunity, revealing the crucial role of the natural autoimmunity network in acting as a frontline defense against infections and facilitating the prompt clearance of dead cells and cell debris. Recent studies have shed light on how natural immunity contributes to the efficacy of vaccinations and aids in defending against mutated and tumorous cells. These aspects collectively form vital components of physiological immune regulation.
Simultaneously, the genetic backdrop and individual status of the physiological autoimmune network can render an organism susceptible to a targeted immune response triggered by specific environmental factors, resulting in prolonged attacks on its own structures and the eventual onset of autoimmune diseases.
We invite submissions of original articles, mini reviews, or theoretical papers for consideration in this Special Issue.
Prof. Dr. Péter Németh
Guest Editor
Manuscript Submission Information
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Keywords
- physiologic autoimmunity
- autoimmune diseases
- natural immune system
- pathologic autoimmunity
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