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Natural Compounds: Structural Diversity, Modifications, and Biological Activities

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 20 July 2025 | Viewed by 531

Special Issue Editor


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Guest Editor
Department of Bioactive Products, Faculty of Chemistry, Adam Mickiewicz University, Uniwersytetu Poznańskiego 8, 61-614 Poznan, Poland
Interests: organic chemistry; natural products; structure modeling; organic physicochemistry; spectroscopic analysis

Special Issue Information

Dear Colleagues,

Steroids, as versatile bioactive molecules, have significantly advanced therapeutic development over the last decades. This Special Issue explores the molecular diversity and bioactivity of novel steroids isolated from natural sources, including fungi, plants, and marine invertebrates. Particular attention is given to their unique structural features, such as hydroxylated side chains and rare modifications that confer potent biological activities. These compounds demonstrate a broad spectrum of applications, from anticancer and antidiabetic treatments to antimicrobial and antifungal agents, addressing critical challenges like drug resistance and cancer therapy. Insights gained from these studies aim to enhance the understanding of steroid compounds and accelerate the development of molecularly targeted therapies for complex diseases.

This Special Issue is supervised by Prof. Dr. Tomasz Pospieszny and assisted by MSc. Grzegorz Hajdaś(Adam Mickiewicz University).

Prof. Dr. Tomasz Pospieszny
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • bile acids
  • molecular research
  • biological activity
  • natural products
  • steroids

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Published Papers (1 paper)

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Review

40 pages, 7237 KiB  
Review
Recent Advances in Steroid Discovery: Structural Diversity and Bioactivity of Marine and Terrestrial Steroids
by Grzegorz Hajdaś, Hanna Koenig and Tomasz Pospieszny
Int. J. Mol. Sci. 2025, 26(7), 3203; https://doi.org/10.3390/ijms26073203 - 30 Mar 2025
Viewed by 346
Abstract
Steroids have been pivotal in medicine and biology, with research into their therapeutic potential accelerating over the past few decades. This review examines recent steroid discoveries from marine and terrestrial sources, highlighting both novel compounds and those with newly identified biological activities. The [...] Read more.
Steroids have been pivotal in medicine and biology, with research into their therapeutic potential accelerating over the past few decades. This review examines recent steroid discoveries from marine and terrestrial sources, highlighting both novel compounds and those with newly identified biological activities. The structural diversity of these steroids contributes to their wide range of biological activity, including anticancer, antimicrobial, antidiabetic, anti-inflammatory, and immunomodulatory properties. Particular emphasis is placed on steroids derived from marine invertebrates, fungi, and medicinal plants, which have shown promising therapeutic potential. Advances in analytical techniques such as NMR spectroscopy and mass spectrometry have facilitated the identification of these compounds. These findings emphasize the growing importance of steroids in addressing pressing global health issues, particularly antibiotic resistance and cancer, where new therapeutic strategies are urgently needed. Although many newly identified steroids exhibit potent bioactivity, challenges remain in translating these findings into clinical therapies. Ongoing exploration of natural sources, along with the application of modern synthetic and computational methods, will be crucial in unlocking the full therapeutic potential of steroid-based compounds. Full article
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