Molecules, Volume 24, Issue 22 (November-2 2019) – 190 articles
Cover Story (view full-size image): Chelating bisphosphonate dendrons fitted with oligo(ethylene glycol) chains and terminated by a fluorinated moiety can anchor iron oxide nanoparticles in the phospholipid shells of microbubbles and respond to the presence of a fluorocarbon gas. Here we investigate the miscibility of these dendrons with phospholipids in Langmuir monolayers, as a model interface of microbubble shells. We demonstrate that the dendrons are squeezed out of the mixed monolayers during compression. This suggests that these dendrons can be specifically designed to facilitate the in vivo delivery of magnetic nanoparticles, allowing for the combined use of ultrasound and magnetic resonance for, in particular, tumor imaging. View this paper.
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