Multitarget Ligands

Dear Colleagues,

There are several disorders that cannot be properly treated with the old “one target–one molecule” approach, due to their multifactorial character. The complexity of these diseases suggests exploiting the simultaneous modulation of more than one target, a concept known also as polypharmacology, by using compounds which are able to interact with different macromolecules involved in the disorder under investigation. Even if the success of several drugs can be due to their fortuitous interaction with multiple macromolecules, historically, the design of multitarget-directed ligands was developed to treat Alzheimer’s Disease. Later, this approach was extended to different therapeutic areas, among them cancer, inflammation, pain, and infectious diseases.

This Special Issue aims to collect research papers and short communication to provide an overview on the recent advances in the design, synthesis, and biological evaluation of multitarget ligands for innovative therapeutic treatments.

Prof. Maria Novella Romanelli
Prof. Silvia Dei
Guest Editors

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