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Cu(II)-Catalyzed C-N Coupling of (Hetero)aryl Halides and N-Nucleophiles Promoted by α-Benzoin Oxime

Department of Medicinal Chemistry, Pharmacy School, Jinzhou Medical University, Jinzhou 121001, China
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Author to whom correspondence should be addressed.
Molecules 2019, 24(22), 4177; https://doi.org/10.3390/molecules24224177
Received: 29 October 2019 / Revised: 10 November 2019 / Accepted: 16 November 2019 / Published: 18 November 2019
We first reported the new application of a translate metal chelating ligand α-benzoin oxime for improving Cu-catalyzed C-N coupling reactions. The system could catalyse coupling reactions of (hetero)aryl halides with a wide of nucleophiles (e.g., azoles, piperidine, pyrrolidine and amino acids) in moderate to excellent yields. The protocol allows rapid access to the most common scaffolds found in FDA-approved pharmaceuticals. View Full-Text
Keywords: α-Benzoin oxime; Copper catalyst; (Hetero)aryl halides; N-Nucleophiles; C-N Coupling α-Benzoin oxime; Copper catalyst; (Hetero)aryl halides; N-Nucleophiles; C-N Coupling
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MDPI and ACS Style

Yuan, C.; Zhang, L.; Zhao, Y. Cu(II)-Catalyzed C-N Coupling of (Hetero)aryl Halides and N-Nucleophiles Promoted by α-Benzoin Oxime. Molecules 2019, 24, 4177. https://doi.org/10.3390/molecules24224177

AMA Style

Yuan C, Zhang L, Zhao Y. Cu(II)-Catalyzed C-N Coupling of (Hetero)aryl Halides and N-Nucleophiles Promoted by α-Benzoin Oxime. Molecules. 2019; 24(22):4177. https://doi.org/10.3390/molecules24224177

Chicago/Turabian Style

Yuan, Chunling; Zhang, Lei; Zhao, Yingdai. 2019. "Cu(II)-Catalyzed C-N Coupling of (Hetero)aryl Halides and N-Nucleophiles Promoted by α-Benzoin Oxime" Molecules 24, no. 22: 4177. https://doi.org/10.3390/molecules24224177

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