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Special Issue "Synthetic Antibiofilm Agents: Design, Synthesis and Applications"
Deadline for manuscript submissions: 31 May 2020.
Interests: medical microbiology; antibiotic resistance–mechanisms, epidemiology, reservoirs, antimicrobial strategies; microbial virulence and pathogenicity
Microorganisms represent an important component of the planetary biomass, accounting for ≈70% of the total marine biomass and they mainly adhere to different surfaces, forming biofilms. Besides their essential ecological roles, microbial biofilms could also have negative impacts, such as biofouling, biocorrosion, and antibiotic resistance. Adhered bacteria exhibit phenotypic resistance to antimicrobial agents, being up to 1000 times more resistant than their planktonic counterparts and, thus, very difficult to eradicate with conventional strategies. Many important opportunistic and nosocomial pathogens adhere and develop biofilms on live tissues and implanted medical devices, consequently producing biofilm-associated infections accounting for ≈60–80% of total human infections. The antibiofilm strategies can involve the use of agents that either inhibit or kill microorganisms, or target the expression of adherence and biofilm-associated genes and/or of their regulators. Despite the huge body of research accumulated regarding the development of antibiofilm strategies, many challenges still remain to be addressed for their successful translation into practice. The purpose of the Special Issue “Synthetic Antibiofilm Agents: Design, Synthesis, and Applications” is to address the current progress and challenges for developing reliable antibiofilm strategies based on synthetic agents.
Prof. Mariana Chifiriuc
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Synthesis methodologies for antibiofilm agents
- In vitro and in vivo biofilm models for assessing antibiofilm agents
- Anti-virulence molecules
- Synthetic antibiofilm peptides
- Antibiofilm molecules’ targets
- Drug repurposing
- Anti-fouling agents