Special Issue "Recent Advances in Non-Canonical Nucleic Acid Structures"
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: closed (30 April 2019).
Interests: G-quadruplex DNA; non-canonical DNA structures, ligands, porphyrins, spectroscopy, X-ray crystallography
Interests: DNA/RNA-quadruplexes, smart probes, sequencing, DNA junctions, ligands
The nucleic acids field is moving at an incredible pace, experiencing an unprecedented paradigm shift away from static, carved-in-stone concepts, e.g., the double helix of DNA is a complex database of genetic information waiting to be scanned according to the cellular activity (the "book of life"); or the many RNA found in cells, when not transcriptional noise, mostly act as molecular messengers abiding by the laws of the genetic code. In the current far more dynamic view, the cellular functions of both DNA and RNA rely not only on their sequences but also, and above all, on their tertiary structures, which are diverse (two-, three-, four-stranded architectures), dynamic (moulded by chaperone proteins, unfolded by resolving enzymes), and involved in intricate cellular regulation networks (with a remarkably broad spectrum of biological processes, from gene expression to genome maintenance). In this Special Issue, we wish to provide a snapshot of the current state of the field, focusing on the structural characterization of DNA, RNA, and DNA/RNA non-canonical structures (e.g., G-quadruplexes, i-motifs, three-way DNA junctions), novel methodologies to assess their existence and functional relevance in human cells (e.g., next generation sequencing, optical detection methods), as well as the strategies implemented to gain control over the key cellular events controlled by the non-canonical nucleic acid structures using ever more accurate and versatile molecular tools.
Dr. Liliya Yatsunyk
Dr. David Monchaud
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Non-canonical DNA/RNA structures (G-quadruplex, i-motif, triplex, three-way junctions)
- Structural characterization (e.g. NMR, X-ray crystallographic analyses)
- Biophysics/biochemical investigations (e.g., FRET, CD, PAGE, fluorescence analyses)
- Cell biology (e.g., genetic regulatory networks, transcription/translation controls)
- Non-canonical nucleic acid-binding partners (e.g., small-molecule ligands, proteins)
- Bioinformatics, next-generation sequencing, genome-/transcriptome-wide analyses