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Open AccessArticle

Synthesis and Antimicrobial Activity of Some New Substituted Quinoxalines

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Chemistry Department, Faculty of Science, Taibah University, Yanbu 46423, Saudi Arabia
2
Chemistry Department, Faculty of Science, Alexandria University, P.O. 426 Ibrahemia, Alexandria 21321, Egypt
*
Author to whom correspondence should be addressed.
Molecules 2019, 24(22), 4198; https://doi.org/10.3390/molecules24224198
Received: 12 September 2019 / Revised: 2 November 2019 / Accepted: 12 November 2019 / Published: 19 November 2019
(This article belongs to the Collection Heterocyclic Compounds)
A number of new symmetrically and asymmetrically 2,3-disubstituted quinoxalines were synthesized through functionalization of 2,3-dichloroquinoxaline (2,3-DCQ) with a variety of sulfur and/or nitrogen nucleophiles. The structures of the obtained compounds were established based on their spectral data and elemental analysis. The antimicrobial activity for the prepared compounds was investigated against four bacterial species and two fungal strains. The symmetrically disubstituted quinoxalines 2, 3, 4, and 5 displayed the most significant antibacterial activity, while compounds 6a, 6b, and the pentacyclic compound 10 showed considerable antifungal activity. Furthermore, compounds 3f, 6b showed broad antimicrobial spectrum against most of the tested strains. View Full-Text
Keywords: quinoxalines; antimicrobial; thioether; thioglycolic acid and pentacyclic compounds quinoxalines; antimicrobial; thioether; thioglycolic acid and pentacyclic compounds
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MDPI and ACS Style

El-Atawy, M.A.; Hamed, E.A.; Alhadi, M.; Omar, A.Z. Synthesis and Antimicrobial Activity of Some New Substituted Quinoxalines. Molecules 2019, 24, 4198.

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