Special Issue "Design and Synthesis of Bioactive Compounds"
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: closed (15 May 2019).
Interests: medicinal chemistry; organic synthesis; biotransformations; enzyme inhibitors; organophosphonates; peptide mimetics; natural products in food
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Many drugs available today were discovered by chance. Drug design is aiming to invent and develop novel biologically-active molecules (leads) for targets (e.g., enzyme, receptor, cell, tissues, etc.) in therapeutic areas. For developing such potential leads all known theoretical and experimental knowledge of the physiological targets is applied. Most commonly, these targets are enzymes and thus enzyme inhibitors account for many of the drugs on today’s market and cover many different therapeutic areas. This issue will cover all remaining techniques of drug design, including: rationale search for novel scaffold, computer-aided design, use of multicomponent chemistry, structural analogy approach, structural and topographical mimetics, multitarget drug design including drug repurposing, natural product-based drugs, etc.
Prof. Dr. Paweł Kafarski
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- in silico drug design (for example: pharmacophore, QSAR, CoMFA and CoMSIA), spectrophore technology, virtual high-throughput screening)
- lead optimization
- novel scaffolds
- scaffold hopping
- multicomponent chemistry
- multitarget drugs
- molecular topologies
- topographical similarity
- network-driven drug discovery
- modification of natural products