Journal Menu► ▼ Journal Menu
Journal Browser► ▼ Journal Browser
Table of Contents
Molecules, Volume 24, Issue 21 (November-1 2019)
- Issues are regarded as officially published after their release is announced to the table of contents alert mailing list.
- You may sign up for e-mail alerts to receive table of contents of newly released issues.
- PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.
Cover Story (view full-size image) A new pH sensor based on a substituted aroylhydrazide with a flexible side chain and a terminal [...] Read more. A new pH sensor based on a substituted aroylhydrazide with a flexible side chain and a terminal trimethyl ammonium group (PHA+) was designed and synthesized. The charged chain guarantees excellent solubility in water. The probe is also very soluble in hydrophobic environments and acts as a pH-sensitive fluorophore/chromophore probe. DFT calculations, single-crystal X-ray data, and molecular dynamics simulations were related to the optical behavior. Changes in the fluorescence color with a strong on–off switch effect at neutral pH have been detected, both in solution and in the solid state. The high Stoke shift, the ability to interact with membranes, the sharp response to pH changes, and the solvatochromism make PHA+ the starting point to develop a new generation of biosensors. View this paper.