Molecules, Volume 24, Issue 21 (November-1 2019) – 200 articles
Cover Story (view full-size image): A new pH sensor based on a substituted aroylhydrazide with a flexible side chain and a terminal trimethyl ammonium group (PHA+) was designed and synthesized. The charged chain guarantees excellent solubility in water. The probe is also very soluble in hydrophobic environments and acts as a pH-sensitive fluorophore/chromophore probe. DFT calculations, single-crystal X-ray data, and molecular dynamics simulations were related to the optical behavior. Changes in the fluorescence color with a strong on–off switch effect at neutral pH have been detected, both in solution and in the solid state. The high Stoke shift, the ability to interact with membranes, the sharp response to pH changes, and the solvatochromism make PHA+ the starting point to develop a new generation of biosensors. View this paper.
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