One new coumarin, dryofracoumarin A (
1), and eight known compounds
2–
9 were isolated from
Dryopteris fragrans (L.) Schott. Their structures were established on the basis of extensive spectroscopic data analyses and comparison with reported spectroscopic data. The new compound
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One new coumarin, dryofracoumarin A (
1), and eight known compounds
2–
9 were isolated from
Dryopteris fragrans (L.) Schott. Their structures were established on the basis of extensive spectroscopic data analyses and comparison with reported spectroscopic data. The new compound
1 was determined to be 8-hydroxyl-4-isopropyl-7-methyl-6-methyl-2
H-benzopyran-2-one. Two dimers,
trans- and
cis-3-(3,4-dimethoxyphen-yl)-4-[(
E)-3,4-dimethoxystyryl]cyclohex-1-ene (compounds
8 and 9), were isolated from the
Dryopteris genus for the first time. The other six were esculetin (
2), isoscopoletin (
3), methylphlorbutyrophenone (
4), aspidinol (
5), albicanol (
6) and (
E)-4-(3,4-dimethoxyphen-yl)but-3-en-1-ol (
7). All compounds were evaluated for their cytotoxic effects by the MTT assay. Compounds
2,
3,
8 and
9 showed significantly cytotoxic effects against three cell lines (A549, MCF7 and HepG2),
1 and
5 against two cell lines (A549 and MCF7), and
6 against one cell line (MCF7). Their IC
50 values ranged between 2.73 ± 0.86 μM and 24.14 ± 3.12 μM. These active compounds might be promising lead compounds for the treatment of cancer.
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