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Molecules 2014, 19(3), 3310-3326; doi:10.3390/molecules19033310
Article

Appraisal of Antioxidant and Anti-Inflammatory Activities of Various Extracts from the Fruiting Bodies of Pleurotus florida

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Received: 25 December 2013; in revised form: 28 February 2014 / Accepted: 12 March 2014 / Published: 18 March 2014
(This article belongs to the Section Metabolites)
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Abstract: Pleurotus florida has been widely used for nutritional and medicinal purposes. The present study was conducted to evaluate the antioxidant and anti-inflammatory effects of the fruiting bodies of P. florida extracted with acetone, methanol, and hot water. The antioxidant activities of the acetone and methanol extracts of P. florida showed stronger inhibition of β-carotene-linoleic acid compared to that of the hot water extract. The acetone extract (8 mg/mL) showed a high reducing power of 1.86. The acetone and methanol extracts showed more effective DPPH radical scavenging activities than the hot water extract. The chelating effect of the extracts at lower concentrations was significantly effective compared to that of the positive control. Thirteen phenolic compounds were detected from acetonitrile and hydrochloric acid solvent extracts. Nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression in lipolysaccahride (LPS) stimulated RAW 264.7 cells, a murine macrophage cell line, were inhibited significantly by the mushroom extracts in a concentration dependent manner. The anti-inflammatory activity on carrageenan-induced edema in the rat hind-paw reduced significantly by the mushroom extracts. Therefore, we have demonstrated that P. florida fruiting bodies possess antioxidant and anti-inflammatory activites related to their inhibitory activities on NO production, iNOS protein expression, and carrageenan-induced paw edema in rats. The results suggest that the fruiting bodies of P. florida are a good source of natural antioxidant and anti-inflammatory agents.
Keywords: antioxidant; phenolic compounds; Pleurotus florida; anti-inflammation activity antioxidant; phenolic compounds; Pleurotus florida; anti-inflammation activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Im, K.H.; Nguyen, T.K.; Shin, D.B.; Lee, K.R.; Lee, T.S. Appraisal of Antioxidant and Anti-Inflammatory Activities of Various Extracts from the Fruiting Bodies of Pleurotus florida. Molecules 2014, 19, 3310-3326.

AMA Style

Im KH, Nguyen TK, Shin DB, Lee KR, Lee TS. Appraisal of Antioxidant and Anti-Inflammatory Activities of Various Extracts from the Fruiting Bodies of Pleurotus florida. Molecules. 2014; 19(3):3310-3326.

Chicago/Turabian Style

Im, Kyung H.; Nguyen, Trung K.; Shin, Do B.; Lee, Kyung R.; Lee, Tae S. 2014. "Appraisal of Antioxidant and Anti-Inflammatory Activities of Various Extracts from the Fruiting Bodies of Pleurotus florida." Molecules 19, no. 3: 3310-3326.



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