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Molecules 2014, 19(3), 3489-3507; doi:10.3390/molecules19033489
Article

Antioxidant Activity of Hispidin Oligomers from Medicinal Fungi: A DFT Study

1,* , 1,2, 1,2, 3, 4, 1,2 and 1,2
Received: 30 January 2014; in revised form: 17 March 2014 / Accepted: 17 March 2014 / Published: 21 March 2014
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Abstract: Hispidin oligomers are styrylpyrone pigments isolated from the medicinal fungi Inonotus xeranticus and Phellinus linteus. They exhibit diverse biological activities and strong free radical scavenging activity. To rationalize the antioxidant activity of a series of four hispidin oligomers and determine the favored mechanism involved in free radical scavenging, DFT calculations were carried out at the B3P86/6-31+G (d, p) level of theory in gas and solvent. The results showed that bond dissociation enthalpies of OH groups of hispidin oligomers (ArOH) and spin density delocalization of related radicals (ArO) are the appropriate parameters to clarify the differences between the observed antioxidant activities for the four oligomers. The effect of the number of hydroxyl groups and presence of a catechol moiety conjugated to a double bond on the antioxidant activity were determined. Thermodynamic and kinetic studies showed that the PC-ET mechanism is the main mechanism involved in free radical scavenging. The spin density distribution over phenoxyl radicals allows a better understanding of the hispidin oligomers formation.
Keywords: hispidin; antioxidant activity; DFT; BDE; PC-ET hispidin; antioxidant activity; DFT; BDE; PC-ET
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Anouar, E.H.; Shah, S.A.A.; Hassan, N.B.; Moussaoui, N.E.; Ahmad, R.; Zulkefeli, M.; Weber, J.-F.F. Antioxidant Activity of Hispidin Oligomers from Medicinal Fungi: A DFT Study. Molecules 2014, 19, 3489-3507.

AMA Style

Anouar EH, Shah SAA, Hassan NB, Moussaoui NE, Ahmad R, Zulkefeli M, Weber J-FF. Antioxidant Activity of Hispidin Oligomers from Medicinal Fungi: A DFT Study. Molecules. 2014; 19(3):3489-3507.

Chicago/Turabian Style

Anouar, El H.; Shah, Syed A.A.; Hassan, Normahanim B.; Moussaoui, Najoua E.; Ahmad, Rohaya; Zulkefeli, Mohd; Weber, Jean-Frédéric F. 2014. "Antioxidant Activity of Hispidin Oligomers from Medicinal Fungi: A DFT Study." Molecules 19, no. 3: 3489-3507.


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