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Molecules 2014, 19(3), 2808-2818; doi:10.3390/molecules19032808

Inhibitory Effect of Corn Silk on Skin Pigmentation

1,2,* , 1
1 Korea Food Research Institute, Seongnam 463-746, Korea 2 Department of Food Biotechnology, University of Science and Technology (UST), Daejeon 305-350, Korea 3 Dermapro Co. Ltd., Seoul 156-709, Korea 4 Kwang-Dong Pharmaceutical Co. Ltd, Seoul 137-875, Korea
* Author to whom correspondence should be addressed.
Received: 27 December 2013 / Revised: 21 February 2014 / Accepted: 25 February 2014 / Published: 3 March 2014
(This article belongs to the Section Natural Products)
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In this study, the inhibitory effect of corn silk on melanin production was evaluated. This study was performed to investigate the inhibitory effect of corn silk on melanin production in Melan-A cells by measuring melanin production and protein expression. The corn silk extract applied on Melan-A cells at a concentration of 100 ppm decreased melanin production by 37.2% without cytotoxicity. This was a better result than arbutin, a positive whitening agent, which exhibited a 26.8% melanin production inhibitory effect at the same concentration. The corn silk extract did not suppress tyrosinase activity but greatly reduced the expression of tyrosinase in Melan-A cells. In addition, corn silk extract was applied to the human face with hyperpigmentation, and skin color was measured to examine the degree of skin pigment reduction. The application of corn silk extract on faces with hyperpigmentation significantly reduced skin pigmentation without abnormal reactions. Based on the results above, corn silk has good prospects for use as a material for suppressing skin pigmentation.
Keywords: corn silk; melanin; skin; tyrosinase corn silk; melanin; skin; tyrosinase
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Choi, S.Y.; Lee, Y.; Kim, S.S.; Ju, H.M.; Baek, J.H.; Park, C.-S.; Lee, D.-H. Inhibitory Effect of Corn Silk on Skin Pigmentation. Molecules 2014, 19, 2808-2818.

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