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Molecules 2014, 19(3), 3638-3653; doi:10.3390/molecules19033638
Article

Synthesis of New 1,2,3-Triazol-4-yl-quinazoline Nucleoside and Acyclonucleoside Analogues

1,2, 1,* , 3,* , 4 and 2,*
Received: 13 January 2014 / Revised: 6 March 2014 / Accepted: 17 March 2014 / Published: 24 March 2014
(This article belongs to the Section Medicinal Chemistry)
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Abstract

In this study, we describe the synthesis of 1,4-disustituted-1,2,3-triazolo-quinazoline ribonucleosides or acyclonucleosides by means of 1,3-dipolar cycloaddition between various O or N-alkylated propargyl-quinazoline and 1'-azido-2',3',5'-tri-O-benzoylribose or activated alkylating agents under microwave conditions. None of the compounds selected showed significant anti-HCV activity in vitro.
Keywords: quinazoline ribonucleosides; 1,2,3-triazole-acyclonucleosides; Huisgen cycloaddition; quinazolinone alkylation; HCV quinazoline ribonucleosides; 1,2,3-triazole-acyclonucleosides; Huisgen cycloaddition; quinazolinone alkylation; HCV
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Ouahrouch, A.; Taourirte, M.; Engels, J.W.; Benjelloun, S.; Lazrek, H.B. Synthesis of New 1,2,3-Triazol-4-yl-quinazoline Nucleoside and Acyclonucleoside Analogues. Molecules 2014, 19, 3638-3653.

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