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Molecules 2014, 19(3), 3638-3653; doi:10.3390/molecules19033638

Synthesis of New 1,2,3-Triazol-4-yl-quinazoline Nucleoside and Acyclonucleoside Analogues

1
Laboratory of Bioorganic and Macromolecular Chemistry, Department of Chemistry, Faculty of Sciences and Technology Gueliz (FSTG), BP 549, Marrakech 40000, Morocco
2
Laboratory of Biomolecular and Medicinal Chemistry, Department of Chemistry, Faculty of Sciences Semlalia, Marrakech 40000, Morocco
3
Institute for Organic Chemistry and Chemical Biology, Goethe-University Frankfurt am Main, Max-von-Laue-Strasse 7, D-60438 Frankfurt am Main, Germany
4
Viral Hepatitis Laboratory Pasteur Institute Morocco, 1, Place Louis Pasteur, 20360, Casablanca 20001, Morocco
*
Authors to whom correspondence should be addressed.
Received: 13 January 2014 / Revised: 6 March 2014 / Accepted: 17 March 2014 / Published: 24 March 2014
(This article belongs to the Section Medicinal Chemistry)
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Abstract

In this study, we describe the synthesis of 1,4-disustituted-1,2,3-triazolo-quinazoline ribonucleosides or acyclonucleosides by means of 1,3-dipolar cycloaddition between various O or N-alkylated propargyl-quinazoline and 1'-azido-2',3',5'-tri-O-benzoylribose or activated alkylating agents under microwave conditions. None of the compounds selected showed significant anti-HCV activity in vitro.
Keywords: quinazoline ribonucleosides; 1,2,3-triazole-acyclonucleosides; Huisgen cycloaddition; quinazolinone alkylation; HCV quinazoline ribonucleosides; 1,2,3-triazole-acyclonucleosides; Huisgen cycloaddition; quinazolinone alkylation; HCV
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Ouahrouch, A.; Taourirte, M.; Engels, J.W.; Benjelloun, S.; Lazrek, H.B. Synthesis of New 1,2,3-Triazol-4-yl-quinazoline Nucleoside and Acyclonucleoside Analogues. Molecules 2014, 19, 3638-3653.

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