Molecules 2014, 19(3), 3135-3148; doi:10.3390/molecules19033135
Article

Synthesis of PNA Oligoether Conjugates

1email, 2email, 1,3email and 1,* email
Received: 21 January 2014; in revised form: 1 March 2014 / Accepted: 4 March 2014 / Published: 13 March 2014
(This article belongs to the Special Issue Bioconjugations)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Several different approaches have been explored for conjugation of oligoethers to PNA with internally or N-terminal placed diaminopropionic acid residues. Single and double conjugation of 2-(2-(2-aminoethoxy)ethoxy)ethanol was obtained using carbonyldimidazole. Using a post PNA-assembly coupling procedure the building block 2-(2-(2-(benzoyloxy)ethoxy)ethoxy)acetic acid multiple attachment of 2-(2-(2-hydroxyethoxy)ethoxy)acetyl groups to both N-terminal and β-amino groups of inserted diaminopropionic acids residues was achieved. Use of a new oligoether functionalized amino acid allows inclusion of oligoether conjugates during on-line machine assisted synthesis which also allowed combination of methods for attachment of different oligoethers and co-conjugation of neocuproine as well as conjugation of an aminosugar.
Keywords: peptide nucleic acid; polyethyleneglycol; aminosugar; neocuproine
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MDPI and ACS Style

Ghidini, A.; Steunenberg, P.; Murtola, M.; Strömberg, R. Synthesis of PNA Oligoether Conjugates. Molecules 2014, 19, 3135-3148.

AMA Style

Ghidini A, Steunenberg P, Murtola M, Strömberg R. Synthesis of PNA Oligoether Conjugates. Molecules. 2014; 19(3):3135-3148.

Chicago/Turabian Style

Ghidini, Alice; Steunenberg, Peter; Murtola, Merita; Strömberg, Roger. 2014. "Synthesis of PNA Oligoether Conjugates." Molecules 19, no. 3: 3135-3148.

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