Synthesis of PNA Oligoether Conjugates
AbstractSeveral different approaches have been explored for conjugation of oligoethers to PNA with internally or N-terminal placed diaminopropionic acid residues. Single and double conjugation of 2-(2-(2-aminoethoxy)ethoxy)ethanol was obtained using carbonyldimidazole. Using a post PNA-assembly coupling procedure the building block 2-(2-(2-(benzoyloxy)ethoxy)ethoxy)acetic acid multiple attachment of 2-(2-(2-hydroxyethoxy)ethoxy)acetyl groups to both N-terminal and β-amino groups of inserted diaminopropionic acids residues was achieved. Use of a new oligoether functionalized amino acid allows inclusion of oligoether conjugates during on-line machine assisted synthesis which also allowed combination of methods for attachment of different oligoethers and co-conjugation of neocuproine as well as conjugation of an aminosugar.
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Ghidini, A.; Steunenberg, P.; Murtola, M.; Strömberg, R. Synthesis of PNA Oligoether Conjugates. Molecules 2014, 19, 3135-3148.
Ghidini A, Steunenberg P, Murtola M, Strömberg R. Synthesis of PNA Oligoether Conjugates. Molecules. 2014; 19(3):3135-3148.Chicago/Turabian Style
Ghidini, Alice; Steunenberg, Peter; Murtola, Merita; Strömberg, Roger. 2014. "Synthesis of PNA Oligoether Conjugates." Molecules 19, no. 3: 3135-3148.