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New Thiophene and Flavonoid from Tagetes minuta Leaves Growing in Saudi Arabia
AbstractPhytochemical investigation of the methanolic extract of Tagetes minuta L. (Asteraceae) leaves resulted in the isolation and identification of two new compounds: 5-methyl-2,2',5',2'',5'',2''',5''',2''''-quinquethiophene (1) and quercetagetin-6-O-(6-O-caffeoyl-β-D-glucopyranoside) (9), in addition to seven known compounds: quercetin-3,6-dimethyl ether (2), quercetin-3-methyl ether (3), quercetin (4), axillarin-7-O-β-D-glucopyranoside (5), quercetagetin-3,7-dimethoxy-6-O-β-D-glucopyranoside (6), quercetagetin-7-methoxy-6-O-β-D-glucopyranoside (7), and quercetagetin-6-O-β-D-glucopyranoside (8). The compounds were identified by UV, IR, 1D, 2D NMR, and HRESIMS spectral data. They showed significant antioxidant activity, comparable with that of propyl gallate. Compounds 8 and 3 showed weak to moderate antileishmanial and antimalarial activities, with IC50 values of 31.0 μg/mL and 4.37 μg/mL, respectively.
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Al-Musayeib, N.M.; Mohamed, G.A.; Ibrahim, S.R.M.; Ross, S.A. New Thiophene and Flavonoid from Tagetes minuta Leaves Growing in Saudi Arabia. Molecules 2014, 19, 2819-2828.View more citation formats
Al-Musayeib NM, Mohamed GA, Ibrahim SRM, Ross SA. New Thiophene and Flavonoid from Tagetes minuta Leaves Growing in Saudi Arabia. Molecules. 2014; 19(3):2819-2828.Chicago/Turabian Style
Al-Musayeib, Nawal M.; Mohamed, Gamal A.; Ibrahim, Sabrin R.M.; Ross, Samir A. 2014. "New Thiophene and Flavonoid from Tagetes minuta Leaves Growing in Saudi Arabia." Molecules 19, no. 3: 2819-2828.