Special Issue "Advances in Medicinal Chemistry of Antifungals"
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: 30 October 2013
Dr. Malgorzata Kostecka
Department of Chemistry, Faculty of Food Science and Biotechnology, University of Life Science, ul. Akademicka 15, 20-950 Lublin, Poland
Interests: drug discovery; synthesis of biologically active compounds; QSAR dependences; antifungal activity; molds
The past decade witnessed numerous advancements in research efforts aiming to synthesize new compounds with antibacterial, antiviral, antifungal, anti-tuberculosis and anti-malaria properties. Those efforts are undertaken to engineer modern fungicides, pesticides and drugs with a broad spectrum of activity and low toxicity for which resistance had not developed. The search for new antifungal drugs is spurred by the dramatic increase in the incidence of fungal infections, growing primary and secondary resistance to popular drugs and the emergence of strains with decreased sensitivity. Molds are the serious problem in modern agriculture. Fusarium infections have been long studied in grain. Recent years witnessed a significant increase in the number of mold contaminations in farm crops and a growing content of mycotoxins, toxic fungal metabolites, in grain. Newest research findings have demonstrated that food and feed contamination may cause serious diseases affecting humans and animals. Fungicides are applied to limit the harmful effects of mycotoxins. The prolonged use of standard combinations of crop protection agents is not always effective.
This special issue is aimed at presenting promising experimental data on structure- lipophilicity- biological activity relationships (SAR). Molecules can be structurally modified with various substituents to produce derivatives whose fungicidal activity is superior to popular fungicides or drugs. New synthesis of compounds with high biological activity should be chance on braving microorganisms.
Dr. Małgorzata Kostecka
- antifungal agents
Article: Synthesis of a New Group of Aliphatic Hydrazide Derivatives and the Correlations between Their Molecular Structure and Biological Activity
Molecules 2012, 17(3), 3560-3573; doi:10.3390/molecules17033560
Received: 25 January 2012; in revised form: 24 February 2012 / Accepted: 14 March 2012 / Published: 22 March 2012| Download PDF Full-text (250 KB)
Article: Antifungal Activity of Salicylanilides and Their Esters with 4-(Trifluoromethyl)benzoic Acid
Molecules 2012, 17(8), 9426-9442; doi:10.3390/molecules17089426
Received: 19 June 2012; in revised form: 19 July 2012 / Accepted: 30 July 2012 / Published: 7 August 2012| Download PDF Full-text (252 KB) | Download XML Full-text
Molecules 2012, 17(11), 13483-13502; doi:10.3390/molecules171113483
Received: 8 October 2012; in revised form: 7 November 2012 / Accepted: 8 November 2012 / Published: 14 November 2012| Download PDF Full-text (263 KB) |
Molecules 2012, 17(12), 14022-14036; doi:10.3390/molecules171214022
Received: 15 October 2012; in revised form: 14 November 2012 / Accepted: 15 November 2012 / Published: 27 November 2012| Download PDF Full-text (303 KB)
Article: Antifungal Activity of Thymus vulgaris L. Essential Oil and Its Constituent Phytochemicals against Rhizopus oryzae: Interaction with Ergosterol
Molecules 2012, 17(12), 14418-14433; doi:10.3390/molecules171214418
Received: 19 October 2012; in revised form: 31 October 2012 / Accepted: 20 November 2012 / Published: 5 December 2012| Download PDF Full-text (236 KB)
Last update: 2 May 2013