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Molecules 2014, 19(3), 3345-3355; doi:10.3390/molecules19033345

Compounds from Dryopteris Fragrans (L.) Schott with Cytotoxic Activity

, 2
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 and 1,*
Received: 7 February 2014 / Revised: 12 March 2014 / Accepted: 13 March 2014 / Published: 18 March 2014
(This article belongs to the Section Metabolites)
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Abstract: One new coumarin, dryofracoumarin A (1), and eight known compounds 29 were isolated from Dryopteris fragrans (L.) Schott. Their structures were established on the basis of extensive spectroscopic data analyses and comparison with reported spectroscopic data. The new compound 1 was determined to be 8-hydroxyl-4-isopropyl-7-methyl-6-methyl-2H-benzopyran-2-one. Two dimers, trans- and cis-3-(3,4-dimethoxyphen-yl)-4-[(E)-3,4-dimethoxystyryl]cyclohex-1-ene (compounds 8 and 9), were isolated from the Dryopteris genus for the first time. The other six were esculetin (2), isoscopoletin (3), methylphlorbutyrophenone (4), aspidinol (5), albicanol (6) and (E)-4-(3,4-dimethoxyphen-yl)but-3-en-1-ol (7). All compounds were evaluated for their cytotoxic effects by the MTT assay. Compounds 2, 3, 8 and 9 showed significantly cytotoxic effects against three cell lines (A549, MCF7 and HepG2), 1 and 5 against two cell lines (A549 and MCF7), and 6 against one cell line (MCF7). Their IC50 values ranged between 2.73 ± 0.86 μM and 24.14 ± 3.12 μM. These active compounds might be promising lead compounds for the treatment of cancer.
Keywords: Dryopteris fragrans (L.) Schott; compounds; MTT; cytotoxic activity Dryopteris fragrans (L.) Schott; compounds; MTT; cytotoxic activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Zhao, D.-D.; Zhao, Q.-S.; Liu, L.; Chen, Z.-Q.; Zeng, W.-M.; Lei, H.; Zhang, Y.-L. Compounds from Dryopteris Fragrans (L.) Schott with Cytotoxic Activity. Molecules 2014, 19, 3345-3355.

AMA Style

Zhao D-D, Zhao Q-S, Liu L, Chen Z-Q, Zeng W-M, Lei H, Zhang Y-L. Compounds from Dryopteris Fragrans (L.) Schott with Cytotoxic Activity. Molecules. 2014; 19(3):3345-3355.

Chicago/Turabian Style

Zhao, Dan-Dan; Zhao, Qin-Shi; Liu, Li; Chen, Zhong-Qin; Zeng, Wei-Min; Lei, Hong; Zhang, Yan-Long. 2014. "Compounds from Dryopteris Fragrans (L.) Schott with Cytotoxic Activity." Molecules 19, no. 3: 3345-3355.

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