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Molecules 2014, 19(3), 3173-3180; doi:10.3390/molecules19033173
Communication

Antibacterial Effects of Afzelin Isolated from Cornus macrophylla on Pseudomonas aeruginosa, A Leading Cause of Illness in Immunocompromised Individuals

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1,4
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3,*  and 1,4,*
1 Department of Dermatological Health Management, College of Health Science, Eulji University, Seongna-Si, 461-713 Gyeonggi-Do, Korea 2 Department of Life Science, Gachon University, San 65, Bokjeong-Dong, Sujeong-Gu, Seongnam-Si, 461-701 Gyeonggi-Do, Korea 3 Department of Genetic Engineering, Sungkyunkwan University, Suwon-Si, 440-746 Gyeonggi-Do, Korea 4 Department of Senior Healthcare, BK21 plus program, Graduated school, Eulji University, Seongna-Si, 461-713 Gyeonggi-Do, Korea
* Authors to whom correspondence should be addressed.
Received: 7 February 2014 / Revised: 10 March 2014 / Accepted: 10 March 2014 / Published: 17 March 2014
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Abstract

The crude ethyl acetate extract of the leaves of Cornus macrophylla showed antibacterial activity against Pseudomonas aeruginosa, a leading cause of illness in immunocompromised individuals. Bioactivity-guided separation led to the isolation of kaempferol 3-O-α-L-rhamnopyranoside (afzelin). The structure was determined based on evaluation of its spectroscopic (UV, MS, and NMR) data. The minimum inhibitory concentration (MIC) of afzelin against Pseudomonas aeruginosa was found to be 31 µg/mL. In addition, the results indicated that a hydroxyl group at C3 of the C-ring of the flavone skeleton and the rhamnose group may act as a negative factor and an enhancing factor, respectively, in the antibacterial activities of afzelin.
Keywords: Cornus macrophylla; antibacterial activity; kaempferol 3-O-α-L-rhamnopyranoside; Pseudomonas aeruginosa Cornus macrophylla; antibacterial activity; kaempferol 3-O-α-L-rhamnopyranoside; Pseudomonas aeruginosa
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Lee, S.Y.; So, Y.-J.; Shin, M.S.; Cho, J.Y.; Lee, J. Antibacterial Effects of Afzelin Isolated from Cornus macrophylla on Pseudomonas aeruginosa, A Leading Cause of Illness in Immunocompromised Individuals. Molecules 2014, 19, 3173-3180.

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