Next Article in Journal
Sesquiterpenes from the Brazilian Red Alga Laurencia dendroidea J. Agardh
Previous Article in Journal
Extract from Armoracia rusticana and Its Flavonoid Components Protect Human Lymphocytes against Oxidative Damage Induced by Hydrogen Peroxide
Molecules 2014, 19(3), 3173-3180; doi:10.3390/molecules19033173
Communication

Antibacterial Effects of Afzelin Isolated from Cornus macrophylla on Pseudomonas aeruginosa, A Leading Cause of Illness in Immunocompromised Individuals

2
,
1
,
1,4
,
3,*  and 1,4,*
Received: 7 February 2014 / Revised: 10 March 2014 / Accepted: 10 March 2014 / Published: 17 March 2014
View Full-Text   |   Download PDF [466 KB, uploaded 18 June 2014]   |   Browse Figures

Abstract

The crude ethyl acetate extract of the leaves of Cornus macrophylla showed antibacterial activity against Pseudomonas aeruginosa, a leading cause of illness in immunocompromised individuals. Bioactivity-guided separation led to the isolation of kaempferol 3-O-α-L-rhamnopyranoside (afzelin). The structure was determined based on evaluation of its spectroscopic (UV, MS, and NMR) data. The minimum inhibitory concentration (MIC) of afzelin against Pseudomonas aeruginosa was found to be 31 µg/mL. In addition, the results indicated that a hydroxyl group at C3 of the C-ring of the flavone skeleton and the rhamnose group may act as a negative factor and an enhancing factor, respectively, in the antibacterial activities of afzelin.
Keywords: Cornus macrophylla; antibacterial activity; kaempferol 3-O-α-L-rhamnopyranoside; Pseudomonas aeruginosa Cornus macrophylla; antibacterial activity; kaempferol 3-O-α-L-rhamnopyranoside; Pseudomonas aeruginosa
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Lee, S.Y.; So, Y.-J.; Shin, M.S.; Cho, J.Y.; Lee, J. Antibacterial Effects of Afzelin Isolated from Cornus macrophylla on Pseudomonas aeruginosa, A Leading Cause of Illness in Immunocompromised Individuals. Molecules 2014, 19, 3173-3180.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert