Special Issue "Fatty Acids"
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: closed (31 December 2013)
Prof. Dr. Andrew Sinclair
School of Medicine, Deakin University, Waum Ponds, VIC 3217, Australia
Interests: nutrition; functional foods; human health; neuroscience; omega 3 fatty acids
Fatty acids play important roles in vertebrates, invertebrates, microbes and plants. In mammals they are found in cellular membranes as components of the phospholipids, as sources of energy (via beta-oxidation), as signaling molecules (certain polyunsaturated fatty acids such as arachidonic acid), as precursors to bioactive compounds in various tissues (eicosanoids, resolvins, neuroprotectins and related compounds), and as organic compounds capable of influencing gene expression in various tissues.
There continues to be controversy over which types of saturated fatty acids are ‘most harmful’; whether trans fatty acids from industrial sources or ruminant sources have the same biological properties; whether positional distribution of fatty acids on glycerol backbone of triacylglycerols is biologically meaningful; whether linoleic acid is as cardioprotective as previously thought; which omega 3 fatty acids are important to human health and whether medium chain fatty acids have a role in health? Furthermore, there is an ongoing debate about the capacity of humans and other species to effectively metabolise linolenic acid to the longer chain omega 3 fatty acid (DHA). In terms of brain health controversy exists over the roles of EPA and DHA (and even DPA) in development, depression and other neuropsychological disorders. It is still not clear how the polyunsaturated fatty acids are transported to the brain and how these are delivered to neurons, astrocytes and oligodendroglial cells.
Plants are capable of synthesizing a wide range of fatty acids, with much of these being stored in the seeds in the TAG form. Recent advances in gene technology has lead to the ‘engineering’ of the composition of the fatty acids in different oilseed plants. Furthermore, in plants, highly unsaturated fatty acids are precursors to hydroxy fatty acids, known as oxylipins, which play a role in inflammatory processes.
Fatty acids are found in microbes and generally are different to those present in mammals and plants, with straight chain, branched chain and monounsaturates predominating. There is a significant effort being made to identify species of microbes living in the marine environment as potential sources of long chain omega 3 fatty acids. Gut microbiota can make short chain fatty acids which are regarded as important for gut health, but is this the only property of these fatty acids in the gut (do they play a role systemically?).
A novel source of fatty acids has been created by the search for oil-bearing marine microalgae or phytoplankton, for omega 3 fatty acids or even as a potential biofuel. Certain fungi are also being used to produce polyunsaturated fatty acids such as arachidonic acid.
Recent developments in the application of lipidomic technologies have increased our understanding of the importance of these tools to allow much greater insight into the role of individual fatty acids in cells.
The objective of this special issue of Molecules is to highlight the latest breakthroughs in the exploration and in the applications of fatty acids, covering all aspects in different species of vertebrates, invertebrates, plants and micro-organisms.
Dr. Andrew Sinclair
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.
- saturated fatty acids
- short chain fatty acids
- medium chain fatty acids
- monounsaturated fatty acids
- trans fatty acids
- hydroxy fatty acids
- furan fatty acids
- polyunsaturated fatty acids
- omega 3 fatty acids
- omega 6 fatty acids
- nutritional biochemistry
- effects on gene, protein and metabolite expression
- analytical chemistry, lipidomics
- medical physiology
Molecules 2014, 19(4), 4708-4744; doi:10.3390/molecules19044708
Received: 26 February 2014; in revised form: 8 April 2014 / Accepted: 8 April 2014 / Published: 15 April 2014| Download PDF Full-text (1421 KB)
Article: Synthesis of All-Z-1,6,9,12,15-Octadecapenten-3-one, A Vinyl Ketone Polyunsaturated Marine Natural Product Isolated from Callysponga sp.
Molecules 2014, 19(3), 3804-3812; doi:10.3390/molecules19033804
Received: 31 December 2013; in revised form: 7 March 2014 / Accepted: 10 March 2014 / Published: 24 March 2014| Download PDF Full-text (212 KB)
Article: Omega-3 Fatty Acids Protect Renal Functions by Increasing Docosahexaenoic Acid-Derived Metabolite Levels in SHR.Cg-Leprcp/NDmcr Rats, a Metabolic Syndrome Model
Molecules 2014, 19(3), 3247-3263; doi:10.3390/molecules19033247
Received: 30 December 2013; in revised form: 7 March 2014 / Accepted: 7 March 2014 / Published: 17 March 2014| Download PDF Full-text (647 KB) | Download XML Full-text | Supplementary Files
Article: Fatty Acids from Pool Lipids as Possible Precursors of the Male Marking Pheromone in Bumblebees
Molecules 2014, 19(2), 2330-2343; doi:10.3390/molecules19022330
Received: 31 December 2013; in revised form: 14 February 2014 / Accepted: 14 February 2014 / Published: 21 February 2014| Download PDF Full-text (284 KB) | View HTML Full-text | Download XML Full-text | Supplementary Files
Article: Fatty Acid Profile of Cheese from Dairy Goats Fed a Diet Enriched with Castor, Sesame and Faveleira Vegetable Oils
Molecules 2014, 19(1), 992-1003; doi:10.3390/molecules19010992
Received: 18 November 2013; in revised form: 7 January 2014 / Accepted: 8 January 2014 / Published: 15 January 2014| Download PDF Full-text (221 KB) | View HTML Full-text | Download XML Full-text
Article: Discrimination of Multi-Origin Chinese Herbal Medicines Using Gas Chromatography-Mass Spectrometry-Based Fatty Acid Profiling
Molecules 2013, 18(12), 15329-15343; doi:10.3390/molecules181215329
Received: 5 November 2013; in revised form: 3 December 2013 / Accepted: 5 December 2013 / Published: 11 December 2013| Download PDF Full-text (1914 KB)
Article: Maternal High Fat Feeding Does Not Have Long-Lasting Effects on Body Composition and Bone Health in Female and Male Wistar Rat Offspring at Young Adulthood
Molecules 2013, 18(12), 15094-15109; doi:10.3390/molecules181215094
Received: 30 October 2013; in revised form: 27 November 2013 / Accepted: 3 December 2013 / Published: 6 December 2013| Download PDF Full-text (320 KB)
Article: Multiplexed Analysis of Cage and Cage Free Chicken Egg Fatty Acids Using Stable Isotope Labeling and Mass Spectrometry
Molecules 2013, 18(12), 14977-14988; doi:10.3390/molecules181214977
Received: 23 September 2013; in revised form: 29 November 2013 / Accepted: 2 December 2013 / Published: 5 December 2013| Download PDF Full-text (296 KB)
Review: Investigating the Role of Polyunsaturated Fatty Acids in Bone Development Using Animal Models
Molecules 2013, 18(11), 14203-14227; doi:10.3390/molecules181114203
Received: 13 September 2013; in revised form: 7 November 2013 / Accepted: 8 November 2013 / Published: 15 November 2013| Download PDF Full-text (446 KB)
Last update: 19 June 2013