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Molecules 2014, 19(3), 3607-3616; doi:10.3390/molecules19033607

Antimicrobial Activities against Periodontopathic Bacteria of Pittosporum tobira and Its Active Compound

1
Department of Maxillofacial Biomedical Engineering, School of Dentistry, Kyung Hee University, Kyunghee Daero 26, Dongdaemungu, Seoul 130-701, Korea
2
Department of Life Science, Gachon University, Seongnam Daero 1342, Seongnam, Gyeonggi-Do 461-701, Korea
3
Institute of Oral Biology, Kyung Hee University, Kyunghee Daero 26, Dongdaemungu, Seoul 130-701, Korea
4
Department of Biological & Environmental Science, Dongguk University, Pildongro-1gil 30, Junggu, Seoul 100-715, Korea
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 23 December 2013 / Revised: 18 March 2014 / Accepted: 18 March 2014 / Published: 24 March 2014
(This article belongs to the Section Natural Products)
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Abstract

The study of medicinal plants for treatment of periodontitis is of great value to establish their efficacy as sources of new antimicrobial drugs. Five hundred and fifty eight Korean local plant extracts were screened for antibacterial activity against representative periodontopathic bacteria such as Porphyromonas gingivalis, Prevotella intermedia, and Fusobacterium nucleatum. Among the various medicinal plants, the alcohol extract of Pittosporum tobira, which significantly exhibited antibacterial effect for all tested strains, showed the highest activity in the antimicrobial assays. NMR analyses revealed that R1-barrigenol, a triterpene sapogenin, was the most effective compound in P. tobira. These results demonstrated that P. tobira possesses antimicrobial properties and would be beneficial for the prevention and treatment of periodontitis.
Keywords: periodonititis; Pittosporium tobira; natural products; R1-barrigenol; triterpene sapogenin periodonititis; Pittosporium tobira; natural products; R1-barrigenol; triterpene sapogenin
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Oh, J.-H.; Jeong, Y.J.; Koo, H.J.; Park, D.W.; Kang, S.C.; Khoa, H.V.B.; Le, L.B.; Cho, J.H.; Lee, J.-Y. Antimicrobial Activities against Periodontopathic Bacteria of Pittosporum tobira and Its Active Compound. Molecules 2014, 19, 3607-3616.

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