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Molecules 2014, 19(3), 3607-3616; doi:10.3390/molecules19033607
Article

Antimicrobial Activities against Periodontopathic Bacteria of Pittosporum tobira and Its Active Compound

1,3,†, 2,†, 2, 2, 2,* , 4, 4, 4 and 1,3,*
Received: 23 December 2013; in revised form: 18 March 2014 / Accepted: 18 March 2014 / Published: 24 March 2014
(This article belongs to the Section Metabolites)
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Abstract: The study of medicinal plants for treatment of periodontitis is of great value to establish their efficacy as sources of new antimicrobial drugs. Five hundred and fifty eight Korean local plant extracts were screened for antibacterial activity against representative periodontopathic bacteria such as Porphyromonas gingivalis, Prevotella intermedia, and Fusobacterium nucleatum. Among the various medicinal plants, the alcohol extract of Pittosporum tobira, which significantly exhibited antibacterial effect for all tested strains, showed the highest activity in the antimicrobial assays. NMR analyses revealed that R1-barrigenol, a triterpene sapogenin, was the most effective compound in P. tobira. These results demonstrated that P. tobira possesses antimicrobial properties and would be beneficial for the prevention and treatment of periodontitis.
Keywords: periodonititis; Pittosporium tobira; natural products; R1-barrigenol; triterpene sapogenin periodonititis; Pittosporium tobira; natural products; R1-barrigenol; triterpene sapogenin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Oh, J.-H.; Jeong, Y.J.; Koo, H.J.; Park, D.W.; Kang, S.C.; Khoa, H.V.B.; Le, L.B.; Cho, J.H.; Lee, J.-Y. Antimicrobial Activities against Periodontopathic Bacteria of Pittosporum tobira and Its Active Compound. Molecules 2014, 19, 3607-3616.

AMA Style

Oh J-H, Jeong YJ, Koo HJ, Park DW, Kang SC, Khoa HVB, Le LB, Cho JH, Lee J-Y. Antimicrobial Activities against Periodontopathic Bacteria of Pittosporum tobira and Its Active Compound. Molecules. 2014; 19(3):3607-3616.

Chicago/Turabian Style

Oh, Jung-Hyun; Jeong, Yong J.; Koo, Hyun J.; Park, Dae W.; Kang, Se C.; Khoa, Hoang V.B.; Le, Le B.; Cho, Joon H.; Lee, Jin-Yong. 2014. "Antimicrobial Activities against Periodontopathic Bacteria of Pittosporum tobira and Its Active Compound." Molecules 19, no. 3: 3607-3616.


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