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Molecules 2014, 19(3), 3055-3067; doi:10.3390/molecules19033055

Five New Alkaloids from the Stem Bark of Daphniphyllum macropodum

1
Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China
2
Institute of Materia Medica, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China
*
Author to whom correspondence should be addressed.
Received: 11 February 2014 / Revised: 25 February 2014 / Accepted: 26 February 2014 / Published: 10 March 2014
(This article belongs to the collection Bioactive Compounds)
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Abstract

Five new alkaloids, daphnicyclidins M and N (compounds 1 and 2) and calyciphyllines Q–S (compounds 35), along with four known ones, paxiphylline C (6), macropodumine B (7), macropodumine C (8) and daphnicyclidin A (9) were isolated from the stem bark of Daphniphyllum macropodum. Calyciphylline Q (3) is the first calyciphylline A derivative possessing a double bond between C-18 and C-19. Their structures and relative configurations were elucidated on the basis of spectroscopic methods, especially 2D NMR techniques. Compounds 1, 2, 8 and 9 exhibited cytotoxic activity against P-388 cells with IC50 values of 5.7, 6.5, 10.3 and 13.8 µM, respectively. Compounds 1 and 2 also showed cytotoxic activity against SGC-7901 cells with IC50 values of 22.4 and 25.6 µM.
Keywords: Daphniphyllum macropodum; daphnicyclidins M and N; calyciphyllines Q–S; alkaloids; cytotoxicity Daphniphyllum macropodum; daphnicyclidins M and N; calyciphyllines Q–S; alkaloids; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Lu, Y.; Gao, K.; Wang, X.; Zhang, W.; Ma, N.; Tang, H. Five New Alkaloids from the Stem Bark of Daphniphyllum macropodum. Molecules 2014, 19, 3055-3067.

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