Abstract: Five new alkaloids, daphnicyclidins M and N (compounds 1 and 2) and calyciphyllines Q–S (compounds 3–5), along with four known ones, paxiphylline C (6), macropodumine B (7), macropodumine C (8) and daphnicyclidin A (9) were isolated from the stem bark of Daphniphyllum macropodum. Calyciphylline Q (3) is the first calyciphylline A derivative possessing a double bond between C-18 and C-19. Their structures and relative configurations were elucidated on the basis of spectroscopic methods, especially 2D NMR techniques. Compounds 1, 2, 8 and 9 exhibited cytotoxic activity against P-388 cells with IC50 values of 5.7, 6.5, 10.3 and 13.8 µM, respectively. Compounds 1 and 2 also showed cytotoxic activity against SGC-7901 cells with IC50 values of 22.4 and 25.6 µM.
Keywords: Daphniphyllum macropodum; daphnicyclidins M and N; calyciphyllines Q–S; alkaloids; cytotoxicity
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Lu, Y.; Gao, K.; Wang, X.; Zhang, W.; Ma, N.; Tang, H. Five New Alkaloids from the Stem Bark of Daphniphyllum macropodum. Molecules 2014, 19, 3055-3067.
Lu Y, Gao K, Wang X, Zhang W, Ma N, Tang H. Five New Alkaloids from the Stem Bark of Daphniphyllum macropodum. Molecules. 2014; 19(3):3055-3067.
Lu, Yunyang; Gao, Kai; Wang, Xiaoyang; Zhang, Wei; Ma, Ning; Tang, Haifeng. 2014. "Five New Alkaloids from the Stem Bark of Daphniphyllum macropodum." Molecules 19, no. 3: 3055-3067.