Next Article in Journal
Next Article in Special Issue
Previous Article in Journal
Previous Article in Special Issue
Molecules 2014, 19(3), 3193-3230; doi:10.3390/molecules19033193
Review

Hyaluronic Acid Conjugates as Vectors for the Active Targeting of Drugs, Genes and Nanocomposites in Cancer Treatment

, ,  and *
Received: 20 January 2014; in revised form: 7 March 2014 / Accepted: 11 March 2014 / Published: 17 March 2014
(This article belongs to the Special Issue Bioconjugations)
View Full-Text   |   Download PDF [583 KB, uploaded 18 June 2014]
Abstract: Hyaluronic acid (HA) is a naturally-occurring glycosaminoglycan and a major component of the extracellular matrix. Low levels of the hyaluronic acid receptor CD44 are found on the surface of epithelial, hematopoietic, and neuronal cells; it is overexpressed in many cancer cells, and in particular in tumor-initiating cells. HA has recently attracted considerable interest in the field of developing drug delivery systems, having been used, as such or encapsulated in different types of nanoassembly, as ligand to prepare nano-platforms for actively targeting drugs, genes, and diagnostic agents. This review describes recent progress made with the several chemical strategies adopted to synthesize conjugates and prepare novel delivery systems with improved behaviors.
Keywords: bioconjugates; drug delivery; hyaluronic acid; anticancer agents; imaging agents; genes bioconjugates; drug delivery; hyaluronic acid; anticancer agents; imaging agents; genes
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Arpicco, S.; Milla, P.; Stella, B.; Dosio, F. Hyaluronic Acid Conjugates as Vectors for the Active Targeting of Drugs, Genes and Nanocomposites in Cancer Treatment. Molecules 2014, 19, 3193-3230.

AMA Style

Arpicco S, Milla P, Stella B, Dosio F. Hyaluronic Acid Conjugates as Vectors for the Active Targeting of Drugs, Genes and Nanocomposites in Cancer Treatment. Molecules. 2014; 19(3):3193-3230.

Chicago/Turabian Style

Arpicco, Silvia; Milla, Paola; Stella, Barbara; Dosio, Franco. 2014. "Hyaluronic Acid Conjugates as Vectors for the Active Targeting of Drugs, Genes and Nanocomposites in Cancer Treatment." Molecules 19, no. 3: 3193-3230.



Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert