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Molecules 2014, 19(3), 3193-3230; doi:10.3390/molecules19033193

Hyaluronic Acid Conjugates as Vectors for the Active Targeting of Drugs, Genes and Nanocomposites in Cancer Treatment

Dipartimento di Scienza e Tecnologia del Farmaco (Department of Drug Science and Technology), University of Torino, Torino, I-10125, Italy
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Received: 20 January 2014 / Revised: 7 March 2014 / Accepted: 11 March 2014 / Published: 17 March 2014
(This article belongs to the Special Issue Bioconjugations)
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Abstract

Hyaluronic acid (HA) is a naturally-occurring glycosaminoglycan and a major component of the extracellular matrix. Low levels of the hyaluronic acid receptor CD44 are found on the surface of epithelial, hematopoietic, and neuronal cells; it is overexpressed in many cancer cells, and in particular in tumor-initiating cells. HA has recently attracted considerable interest in the field of developing drug delivery systems, having been used, as such or encapsulated in different types of nanoassembly, as ligand to prepare nano-platforms for actively targeting drugs, genes, and diagnostic agents. This review describes recent progress made with the several chemical strategies adopted to synthesize conjugates and prepare novel delivery systems with improved behaviors. View Full-Text
Keywords: bioconjugates; drug delivery; hyaluronic acid; anticancer agents; imaging agents; genes bioconjugates; drug delivery; hyaluronic acid; anticancer agents; imaging agents; genes
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Arpicco, S.; Milla, P.; Stella, B.; Dosio, F. Hyaluronic Acid Conjugates as Vectors for the Active Targeting of Drugs, Genes and Nanocomposites in Cancer Treatment. Molecules 2014, 19, 3193-3230.

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