A section of Molecules (ISSN 1420-3049).
The Medicinal Chemistry Section of the journal Molecules publishes original research and review articles that increase our understanding of how the chemical structure of bioactive molecules determines their pharmacodynamic, pharmacokinetic, and physicochemical properties, and, hence their therapeutic potential. In particular, this Section mainly invites contributions that report on:
-The design, synthesis, chemical characterization, and biological evaluation of novel compounds against biological targets of therapeutic, diagnostic, or theranostic interest, and/or the assessment of their physicochemical and pharmacokinetic properties.
-The isolation from herbal plants and separate biological characterization of individual bioactive compounds and/or their semi-synthetic derivatives.
-Hit-to-lead projects that lead to a significant optimization of potency, or physicochemical and/or pharmacokinetic properties.
-Computational, molecular biological, and/or structural biological studies that shed light on the structure and function of biological targets of therapeutic, diagnostic, or theranostic interest and on their interaction with known or novel compounds, thereby enabling the rational design of optimized ligands.
-Computational and biological studies of known drugs or their derivatives that address their interaction with novel biological targets for repositioning purposes.
-Novel synthetic, computational, or biological methodologies of relevance in medicinal chemistry.
-Development and application of materials for medicinal chemistry purposes, such as drug delivery and drug targeting.
Manuscripts that report on the biological evaluation of mixtures of compounds, such as plant extracts, or purely pharmacological studies that look deeper into the standard action of well-established drugs will normally not be considered for publication in this Section.
Following special issues within this section are currently open for submissions:
- 25th Anniversary of the Amyloid Hypothesis and Alzheimer Disease (Deadline: 15 September 2017)
- Anti-inflammatory Agents (Deadline: 30 August 2017)
- Applications of Magnetic Nanoparticles in Biomedicine (Deadline: 20 October 2017)
- Bioactive Compounds for Metabolic Syndrome and Type 2 Diabetes (Deadline: 31 August 2017)
- Biomedical Applications of Polylactide (PLA) and its Copolymers (Deadline: 30 September 2017)
- Chitin and Chitosan Derivatives: Biological Activities and Application (Deadline: 15 October 2017)
- COST CM1307: Targeted Chemotherapy towards Diseases Caused by Endoparasites—Proceedings in Medicinal and Natural Product Chemistry (Deadline: 30 June 2018)
- Current Aspects of Radiopharmaceutical Chemistry (Deadline: 30 January 2018)
- Emerging Drug Discovery Approaches against Infectious Diseases (Deadline: 8 November 2017)
- Frontiers in Computational Chemistry for Drug Discovery (Deadline: 20 September 2017)
- G-Quadruplex Ligands and Cancer (Deadline: 30 December 2017)
- Hyaluronic Acid and its Derivatives for Biomedical Applications (Deadline: 28 February 2018)
- Medicinal Chemistry in Europe (Deadline: 30 January 2018)
- Mesoporous Silica in Biomedical Applications (Deadline: 10 December 2017)
- Metalloenzyme Inhibitors and Activators (Deadline: 28 February 2018)
- Molecular Imaging and Treatment Monitoring of Cancer (Deadline: 10 March 2018)
- Neuroprotective Agents (Deadline: 30 December 2017)
- Phospholipases and Lipases: Targets for Drug Development (Deadline: 28 February 2018)
- Pyrazole Derivatives (Deadline: 30 November 2017)
- Selected Papers from 2017 Chinese Medicinal Chemistry Symposium (CMCS 2017) (Deadline: 30 October 2017)
- Selected Papers from the 46th EuroCongress on Drug Synthesis and Analysis (ECDSA-2017) (Deadline: 30 September 2017)
- The Biomedical Importance of Indoles and Their Derivatives (Deadline: 30 November 2017)
- Transcription Factors as Therapeutic Targets (Deadline: 31 March 2018)
Following topical collections within this section are currently open for submissions:
- Antibiotics & Superbugs: New Strategies to Combat Antimicrobial Resistance
- Herbal Medicine Research
- Molecular Docking
- Novel Drug Candidates for Anticancer Therapy: Design, Preliminary Evaluations, and Further Developments
- Poorly Soluble Drugs
- Poorly Soluble Drugs