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Medicinal Chemistry

A section of Molecules (ISSN 1420-3049).

Section Information

The Medicinal Chemistry Section of the journal Molecules publishes original research and review articles that increase our understanding of how the chemical structure of bioactive molecules determines their pharmacodynamic, pharmacokinetic, and physicochemical properties, and, hence their therapeutic potential. In particular, this Section mainly invites contributions that report on:

-The design, synthesis, chemical characterization, and biological evaluation of novel compounds against biological targets of therapeutic, diagnostic, or theranostic interest, and/or the assessment of their physicochemical and pharmacokinetic properties.

-The isolation from herbal plants and separate biological characterization of individual bioactive compounds and/or their semi-synthetic derivatives.

-Hit-to-lead projects that lead to a significant optimization of potency, or physicochemical and/or pharmacokinetic properties.

-Computational, molecular biological, and/or structural biological studies that shed light on the structure and function of biological targets of therapeutic, diagnostic, or theranostic interest and on their interaction with known or novel compounds, thereby enabling the rational design of optimized ligands.

-Computational and biological studies of known drugs or their derivatives that address their interaction with novel biological targets for repositioning purposes.

-Novel synthetic, computational, or biological methodologies of relevance in medicinal chemistry.

-Development and application of materials for medicinal chemistry purposes, such as drug delivery and drug targeting.

Manuscripts that report on the biological evaluation of mixtures of compounds, such as plant extracts, or purely pharmacological studies that look deeper into the standard action of well-established drugs will normally not be considered for publication in this Section.

Editorial Board

Special Issues

Following special issues within this section are currently open for submissions:

Topical Collections

Following topical collections within this section are currently open for submissions:

Papers Published

Journal Contact

Molecules Editorial Office
St. Alban-Anlage 66, 4052 Basel, Switzerland
Tel. +41 61 683 77 34
Fax: +41 61 302 89 18
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