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Molecules 2014, 19(3), 2733-2747; doi:10.3390/molecules19032733

Chemical Composition, Biological and Cytotoxic Activities of Plant Extracts and Compounds Isolated from Ferula lutea

1
Laboratoire des IMRCP UMR CNRS 5623, Faculté de pharmacie de Toulouse, Université de Toulouse, Université Paul-Sabatier, 118 route de Narbonne, Toulouse F-31062, France
2
Laboratoire de Chimie Hétérocyclique, Produits Naturels et Réactivité (CHPNR), Equipe Chimie Médicinale et Produits Naturels, Département de Chimie, Faculté des Sciences de Monastir, Université de Monastir, Avenue de l'Environnement, Monastir 5019, Tunisia
*
Authors to whom correspondence should be addressed.
Received: 24 December 2013 / Revised: 14 February 2014 / Accepted: 18 February 2014 / Published: 26 February 2014
(This article belongs to the Section Medicinal Chemistry)
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Abstract

The present work describes the phytochemical study on Ferula lutea flowers. Total phenolics and flavonoids of the n-butanol and ethyl acetate extracts were quantified (phenolics [40.68–52.29 mg gallic acid equivalent/g of dry weight], flavonoids [12.38–14.72 mg quercitin/g dry weight]). Two diastereoisomers were isolated and identified using spectroscopic techniques (1D, 2D NMR and GC-MS). The extracts and diastereoisomers were tested for antioxidant, antiacetylcholinesterase, antimicrobial, antidiabectic, cytotoxic (leukemia cell line) activities and allelopathic potentialities. The strongest antioxidant activity was obtained for the ethyl acetate extract (IC50 = 12.8 ± 1.29 µg/mL). The two extracts exhibited high antidiabetic activity (54.1 and 52.1% at 40 µg/mL). View Full-Text
Keywords: Ferula lutea; (+)-Z-deltoin; (−)-E-deltoin; antioxidant; antiacetylcholinesterase; antimicrobial; antidiabetic; cytotoxic; allelopathic Ferula lutea; (+)-Z-deltoin; (−)-E-deltoin; antioxidant; antiacetylcholinesterase; antimicrobial; antidiabetic; cytotoxic; allelopathic
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Znati, M.; Jannet, H.B.; Cazaux, S.; Bouajila, J. Chemical Composition, Biological and Cytotoxic Activities of Plant Extracts and Compounds Isolated from Ferula lutea. Molecules 2014, 19, 2733-2747.

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