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Molecules 2014, 19(3), 2733-2747; doi:10.3390/molecules19032733
Article

Chemical Composition, Biological and Cytotoxic Activities of Plant Extracts and Compounds Isolated from Ferula lutea

1,2, 2,* , 1 and 1,*
Received: 24 December 2013; in revised form: 14 February 2014 / Accepted: 18 February 2014 / Published: 26 February 2014
(This article belongs to the Section Medicinal Chemistry)
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Abstract: The present work describes the phytochemical study on Ferula lutea flowers. Total phenolics and flavonoids of the n-butanol and ethyl acetate extracts were quantified (phenolics [40.68–52.29 mg gallic acid equivalent/g of dry weight], flavonoids [12.38–14.72 mg quercitin/g dry weight]). Two diastereoisomers were isolated and identified using spectroscopic techniques (1D, 2D NMR and GC-MS). The extracts and diastereoisomers were tested for antioxidant, antiacetylcholinesterase, antimicrobial, antidiabectic, cytotoxic (leukemia cell line) activities and allelopathic potentialities. The strongest antioxidant activity was obtained for the ethyl acetate extract (IC50 = 12.8 ± 1.29 µg/mL). The two extracts exhibited high antidiabetic activity (54.1 and 52.1% at 40 µg/mL).
Keywords: Ferula lutea; (+)-Z-deltoin; (−)-E-deltoin; antioxidant; antiacetylcholinesterase; antimicrobial; antidiabetic; cytotoxic; allelopathic Ferula lutea; (+)-Z-deltoin; (−)-E-deltoin; antioxidant; antiacetylcholinesterase; antimicrobial; antidiabetic; cytotoxic; allelopathic
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Znati, M.; Jannet, H.B.; Cazaux, S.; Bouajila, J. Chemical Composition, Biological and Cytotoxic Activities of Plant Extracts and Compounds Isolated from Ferula lutea. Molecules 2014, 19, 2733-2747.

AMA Style

Znati M, Jannet HB, Cazaux S, Bouajila J. Chemical Composition, Biological and Cytotoxic Activities of Plant Extracts and Compounds Isolated from Ferula lutea. Molecules. 2014; 19(3):2733-2747.

Chicago/Turabian Style

Znati, Mansour; Jannet, Hichem B.; Cazaux, Sylvie; Bouajila, Jalloul. 2014. "Chemical Composition, Biological and Cytotoxic Activities of Plant Extracts and Compounds Isolated from Ferula lutea." Molecules 19, no. 3: 2733-2747.


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