Molecules 2014, 19(3), 3264-3273; doi:10.3390/molecules19033264

Cytotoxic Quinones from the Roots of Aloe dawei

1email, 1email, 2email, 3email, 3email, 2email, 1,* email and 3,4,* email
Received: 24 January 2014; in revised form: 5 March 2014 / Accepted: 10 March 2014 / Published: 17 March 2014
(This article belongs to the Section Metabolites)
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Abstract: Seven naphthoquinones and nine anthraquinones were isolated from the roots of Aloe dawei by chromatographic separation. The purified metabolites were identified by NMR and MS analyses. Out of the sixteen quinones, 6-hydroxy-3,5-dimethoxy-2-methyl-1,4-naphthoquinone is a new compound. Two of the isolates, 5,8-dihydroxy-3-methoxy-2-methylnaphthalene-1,4-dione and 1-hydroxy-8-methoxy-3-methylanthraquinone showed high cytotoxic activity (IC50 1.15 and 4.85 µM) on MCF-7 breast cancer cells, whereas the others showed moderate to low cytotoxic activity against MDA-MB-231 (ER Negative) and MCF-7 (ER Positive) cancer cells.
Keywords: Aloe dawei; Asphodelaceae; naphthoquinone; anthraquinone; 6-hydroxy-3,5-dimethoxy-2-methyl-1,4-naphthoquinone; cytotoxicity; MCF-7
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MDPI and ACS Style

Abdissa, N.; Induli, M.; Fitzpatrick, P.; Alao, J.P.; Sunnerhagen, P.; Landberg, G.; Yenesew, A.; Erdélyi, M. Cytotoxic Quinones from the Roots of Aloe dawei. Molecules 2014, 19, 3264-3273.

AMA Style

Abdissa N, Induli M, Fitzpatrick P, Alao JP, Sunnerhagen P, Landberg G, Yenesew A, Erdélyi M. Cytotoxic Quinones from the Roots of Aloe dawei. Molecules. 2014; 19(3):3264-3273.

Chicago/Turabian Style

Abdissa, Negera; Induli, Martha; Fitzpatrick, Paul; Alao, John P.; Sunnerhagen, Per; Landberg, Göran; Yenesew, Abiy; Erdélyi, Máté. 2014. "Cytotoxic Quinones from the Roots of Aloe dawei." Molecules 19, no. 3: 3264-3273.

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