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Molecules 2014, 19(3), 3264-3273; doi:10.3390/molecules19033264

Cytotoxic Quinones from the Roots of Aloe dawei

1
Department of Chemistry, University of Nairobi, P.O. Box 30197, Nairobi 00100, Kenya
2
Sahlgrenska Cancer Centre, University of Gothenburg, Gothenburg SE-405 30, Sweden
3
Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg SE-412 96, Sweden
4
Swedish NMR Centre, University of Gothenburg, Gothenburg SE-405 30, Sweden
*
Authors to whom correspondence should be addressed.
Received: 24 January 2014 / Revised: 5 March 2014 / Accepted: 10 March 2014 / Published: 17 March 2014
(This article belongs to the Section Natural Products)
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Abstract

Seven naphthoquinones and nine anthraquinones were isolated from the roots of Aloe dawei by chromatographic separation. The purified metabolites were identified by NMR and MS analyses. Out of the sixteen quinones, 6-hydroxy-3,5-dimethoxy-2-methyl-1,4-naphthoquinone is a new compound. Two of the isolates, 5,8-dihydroxy-3-methoxy-2-methylnaphthalene-1,4-dione and 1-hydroxy-8-methoxy-3-methylanthraquinone showed high cytotoxic activity (IC50 1.15 and 4.85 µM) on MCF-7 breast cancer cells, whereas the others showed moderate to low cytotoxic activity against MDA-MB-231 (ER Negative) and MCF-7 (ER Positive) cancer cells. View Full-Text
Keywords: Aloe dawei; Asphodelaceae; naphthoquinone; anthraquinone; 6-hydroxy-3,5-dimethoxy-2-methyl-1,4-naphthoquinone; cytotoxicity; MCF-7 Aloe dawei; Asphodelaceae; naphthoquinone; anthraquinone; 6-hydroxy-3,5-dimethoxy-2-methyl-1,4-naphthoquinone; cytotoxicity; MCF-7
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Abdissa, N.; Induli, M.; Fitzpatrick, P.; Alao, J.P.; Sunnerhagen, P.; Landberg, G.; Yenesew, A.; Erdélyi, M. Cytotoxic Quinones from the Roots of Aloe dawei. Molecules 2014, 19, 3264-3273.

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