Next Article in Journal
Computational Study of Electron Delocalization in Hexaarylbenzenes
Previous Article in Journal
Omega-3 Fatty Acids Protect Renal Functions by Increasing Docosahexaenoic Acid-Derived Metabolite Levels in SHR.Cg-Leprcp/NDmcr Rats, a Metabolic Syndrome Model
Molecules 2014, 19(3), 3264-3273; doi:10.3390/molecules19033264
Article

Cytotoxic Quinones from the Roots of Aloe dawei

1
, 1
, 2
, 3
, 3
, 2
, 1,*  and 3,4,*
1 Department of Chemistry, University of Nairobi, P.O. Box 30197, Nairobi 00100, Kenya 2 Sahlgrenska Cancer Centre, University of Gothenburg, Gothenburg SE-405 30, Sweden 3 Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg SE-412 96, Sweden 4 Swedish NMR Centre, University of Gothenburg, Gothenburg SE-405 30, Sweden
* Authors to whom correspondence should be addressed.
Received: 24 January 2014 / Revised: 5 March 2014 / Accepted: 10 March 2014 / Published: 17 March 2014
(This article belongs to the Section Metabolites)
View Full-Text   |   Download PDF [230 KB, uploaded 18 June 2014]   |   Browse Figure

Abstract

Seven naphthoquinones and nine anthraquinones were isolated from the roots of Aloe dawei by chromatographic separation. The purified metabolites were identified by NMR and MS analyses. Out of the sixteen quinones, 6-hydroxy-3,5-dimethoxy-2-methyl-1,4-naphthoquinone is a new compound. Two of the isolates, 5,8-dihydroxy-3-methoxy-2-methylnaphthalene-1,4-dione and 1-hydroxy-8-methoxy-3-methylanthraquinone showed high cytotoxic activity (IC50 1.15 and 4.85 µM) on MCF-7 breast cancer cells, whereas the others showed moderate to low cytotoxic activity against MDA-MB-231 (ER Negative) and MCF-7 (ER Positive) cancer cells.
Keywords: Aloe dawei; Asphodelaceae; naphthoquinone; anthraquinone; 6-hydroxy-3,5-dimethoxy-2-methyl-1,4-naphthoquinone; cytotoxicity; MCF-7 Aloe dawei; Asphodelaceae; naphthoquinone; anthraquinone; 6-hydroxy-3,5-dimethoxy-2-methyl-1,4-naphthoquinone; cytotoxicity; MCF-7
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Export to BibTeX |
EndNote


MDPI and ACS Style

Abdissa, N.; Induli, M.; Fitzpatrick, P.; Alao, J.P.; Sunnerhagen, P.; Landberg, G.; Yenesew, A.; Erdélyi, M. Cytotoxic Quinones from the Roots of Aloe dawei. Molecules 2014, 19, 3264-3273.

View more citation formats

Supplement

Related Articles

Article Metrics

Comments

Citing Articles

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert