Next Article in Journal
Previous Article in Journal
Molecules 2014, 19(3), 3777-3792; doi:10.3390/molecules19033777
Article

Synthesis, Cytotoxic Activity and 2D-QSAR Study of Some Imidazoquinazoline Derivatives

Received: 14 January 2014; in revised form: 17 March 2014 / Accepted: 19 March 2014 / Published: 24 March 2014
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [339 KB, uploaded 18 June 2014]   |   Browse Figures
Abstract: A novel series of 4-substituted amino-7,8-dimethoxy-1-phenylimidazo[1,5-a]quinazolin-5(4H)-one derivatives was designed, synthesized and tested for their antitumor activity against a human mammary carcinoma cell line (MCF7). Compound 5a was found to be the most active derivative. Physico-chemical parameters were also determined and revealed that most of the compounds obeyed the “rule of five” properties with good absorption percentages. 2D-QSAR studies revealed a well predictive and statistically significant and cross validated QSAR model that helps to explore some expectedly potent compounds.
Keywords: imidazolinone; imidazo[1,5-a]quinazoline; antitumor activity; Lipinski’s parameters; 2D-QSAR imidazolinone; imidazo[1,5-a]quinazoline; antitumor activity; Lipinski’s parameters; 2D-QSAR
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Georgey, H. Synthesis, Cytotoxic Activity and 2D-QSAR Study of Some Imidazoquinazoline Derivatives. Molecules 2014, 19, 3777-3792.

AMA Style

Georgey H. Synthesis, Cytotoxic Activity and 2D-QSAR Study of Some Imidazoquinazoline Derivatives. Molecules. 2014; 19(3):3777-3792.

Chicago/Turabian Style

Georgey, Hanan. 2014. "Synthesis, Cytotoxic Activity and 2D-QSAR Study of Some Imidazoquinazoline Derivatives." Molecules 19, no. 3: 3777-3792.



Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert