Special Issue "Structure-Activity Relationship of Flavonoids"
Deadline for manuscript submissions: closed (15 January 2014)
Dr. H.P. Vasantha Rupasinghe
Department of Environmental Sciences, Faculty of Agriculture, Dalhousie University, 50 Pictou Road, Truro, NS B2N 5E3, Canada
Interests: phenolics and isoprenoids; structure-activity relationship of flavonoids; bio-active phytochemicals of fruits, their health benefits and mode of action; Natural products chemistry
Flavonoids are a sub-class of polyphenols that have been shown to possess numerous biological properties in in vitro and pre-clinical experimental models of many chronic diseases. Flavonoids are ubiquitously present in fruits, vegetables, medicinal plants and their products. Scientific evidence have strongly shown that regular intake of dietary flavonoids reduces the risk of oxidative-stress mediated pathogenesis of human disease such as cardiovascular disease, various cancers and neurological disorders but also against aging. The biological properties of dietary flavonoids have been demonstrated to be due to multiple mechanisms of actions including free radical scavenging, transition metal ion chelation, activation of survival genes and signaling pathways, regulation of mitochondrial function and bioenergetics, modulation of inflammation response and even interactions with micro biota. However, activity of flavonoids are not limited to their health promoting benefits but extend to a wide array of ecological interactions of plants such as acting as a signal and defense molecule. Their industrial applications are beyond the limit of nutraceuticals and drug candidate molecules. The diverse biological activities of flavonoid molecules are due to their structural diversity. However, flavonoids have a common C6-C3-C6 structure consisting of two aromatic rings (A and B) linked through a three carbon chain, mostly organized as an oxygenated heterocycle (ring C). Over 10,000 flavonoids that have been characterized can be classified under isoflavones, flavonols, catechins and proanthocyanidins, anthocyanins, flavones, flavanones and chalcones. Despite a large number of publications available within the disciplines of analytical chemistry, biological effects and applications of flavonoids, our understanding of how structure of these molecules related to their interactions with cell components and subsequent activity is still limited. Therefore, this special issue is dedicated for communications in the form of original research and review articles, which cover the flavonoid structure and activity relationships. Review articles could discuss the specific sub-classes of flavonoid molecules or specific activity or group of related activities. If remain within the scope of structure-activity relationship, other non-flavonoid polyphenols can also be considered for this special issue. Authors considering the submission of a review are kindly asked to provide in advance to the guest editor a brief outline of the subject matter of their work.
Dr. H.P. Vasantha Rupasinghe
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.
- biological properties
- antioxidant activity
- pharmacological activity
- oxidative stress
- biochemical mechanism
- enzyme inhibition
- flavonoid analogs and derivatives