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Molecules 2014, 19(3), 3617-3627; doi:10.3390/molecules19033617

Trigocherrierin A, a Potent Inhibitor of Chikungunya Virus Replication

1 EA4267 Epithelial Functions and Dysfunctions, UFR of Medical and Pharmaceutical Sciences, 19 rue Ambroise Paré, 25030 Besançon, France 2 Rega Institute for Medical Research (KU Leuven), Minderbroedersstraat 10, B3000, Leuven, Belgium 3 Gif Research Center, Institute of Chemistry of Natural Substances (ICSN), CNRS, Labex CEBA, 1, avenue de la Terrasse, 91198 Gif sur Yvette Cedex, France
* Author to whom correspondence should be addressed.
Received: 21 February 2014 / Revised: 12 March 2014 / Accepted: 17 March 2014 / Published: 24 March 2014
(This article belongs to the Section Natural Products)
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Trigocherrierin A (1) and trigocherriolide E (2), two new daphnane diterpenoid orthoesters (DDOs), and six chlorinated analogues, trigocherrins A, B, F and trigocherriolides A–C, were isolated from the leaves of Trigonostemon cherrieri. Their structures were identified by mass spectrometry, extensive one- and two-dimensional NMR spectroscopy and through comparison with data reported in the literature. These compounds are potent and selective inhibitors of chikungunya virus (CHIKV) replication. Among the DDOs isolated, compound 1 exhibited the strongest anti-CHIKV activity (EC50 = 0.6 ± 0.1 µM, SI = 71.7).
Keywords: Trigonostemon cherrieri; Euphorbiaceae; chikungunya virus (CHIKV); daphnane diterpenoid orthoester (DDO) Trigonostemon cherrieri; Euphorbiaceae; chikungunya virus (CHIKV); daphnane diterpenoid orthoester (DDO)
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Bourjot, M.; Leyssen, P.; Neyts, J.; Dumontet, V.; Litaudon, M. Trigocherrierin A, a Potent Inhibitor of Chikungunya Virus Replication. Molecules 2014, 19, 3617-3627.

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