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Molecules 2014, 19(3), 3617-3627; doi:10.3390/molecules19033617
Article

Trigocherrierin A, a Potent Inhibitor of Chikungunya Virus Replication

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Received: 21 February 2014; in revised form: 12 March 2014 / Accepted: 17 March 2014 / Published: 24 March 2014
(This article belongs to the Section Metabolites)
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Abstract: Trigocherrierin A (1) and trigocherriolide E (2), two new daphnane diterpenoid orthoesters (DDOs), and six chlorinated analogues, trigocherrins A, B, F and trigocherriolides A–C, were isolated from the leaves of Trigonostemon cherrieri. Their structures were identified by mass spectrometry, extensive one- and two-dimensional NMR spectroscopy and through comparison with data reported in the literature. These compounds are potent and selective inhibitors of chikungunya virus (CHIKV) replication. Among the DDOs isolated, compound 1 exhibited the strongest anti-CHIKV activity (EC50 = 0.6 ± 0.1 µM, SI = 71.7).
Keywords: Trigonostemon cherrieri; Euphorbiaceae; chikungunya virus (CHIKV); daphnane diterpenoid orthoester (DDO) Trigonostemon cherrieri; Euphorbiaceae; chikungunya virus (CHIKV); daphnane diterpenoid orthoester (DDO)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Bourjot, M.; Leyssen, P.; Neyts, J.; Dumontet, V.; Litaudon, M. Trigocherrierin A, a Potent Inhibitor of Chikungunya Virus Replication. Molecules 2014, 19, 3617-3627.

AMA Style

Bourjot M, Leyssen P, Neyts J, Dumontet V, Litaudon M. Trigocherrierin A, a Potent Inhibitor of Chikungunya Virus Replication. Molecules. 2014; 19(3):3617-3627.

Chicago/Turabian Style

Bourjot, Mélanie; Leyssen, Pieter; Neyts, Johan; Dumontet, Vincent; Litaudon, Marc. 2014. "Trigocherrierin A, a Potent Inhibitor of Chikungunya Virus Replication." Molecules 19, no. 3: 3617-3627.


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