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Molecules 2014, 19(3), 3793-3803; doi:10.3390/molecules19033793

Antischistosomal Activity of the Terpene Nerolidol

1
Faculdade de Ciências de Guarulhos (FACIG/UNIESP), Av. Guarulhos, 1844, Guarulhos, SP 07025-000, Brazil
2
Programa de Pós-graduação em Ciências Farmacêuticas, Universidade Federal do Piauí, Teresina, PI 64049-550, Brazil
3
Programa de Pós-graduação em Biotecnologia, Universidade Federal do Piauí, Teresina, PI 64049-550, Brazil
4
Departamento de Ciências Farmacêuticas, Universidade Federal da Paraíba, João Pessoa, PB 58051-900, Brazil
5
Enteroparasitas, Instituto Adolfo Lutz, São Paulo, SP 01246-902, Brazil
*
Author to whom correspondence should be addressed.
Received: 7 January 2014 / Revised: 13 March 2014 / Accepted: 19 March 2014 / Published: 24 March 2014
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Abstract

Schistosomiasis is a neglected tropical disease that affects hundreds of millions of people worldwide. Since the treatment of this disease currently relies on a single drug, praziquantel, new and safe schistosomicidal agents are urgently required. Nerolidol, a sesquiterpene present in the essential oils of several plants, is found in many foods and was approved by the U.S. Food and Drug Administration. In this study we analysed the in vitro antiparasitic effect of nerolidol on Schistosoma mansoni adult worms. Nerolidol at concentrations of 31.2 and 62.5 μM reduced the worm motor activity and caused the death of all male and female schistosomes, respectively. In addition, confocal laser scanning microscopy revealed morphological alterations on the tegument of worms such as disintegration, sloughing and erosion of the surface, and a correlation between viability and tegumental damage was observed. In conclusion, nerolidol may be a promising lead compound for the development of antischistosomal natural agents. View Full-Text
Keywords: Schistosoma; schistosomiasis; nerolidol; schistosomicial activity; natural product; neglected tropical disease; in vitro studies; confocal laser scanning microscopy Schistosoma; schistosomiasis; nerolidol; schistosomicial activity; natural product; neglected tropical disease; in vitro studies; confocal laser scanning microscopy
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Silva, M.P.; Oliveira, G.L.; de Carvalho, R.B.; de Sousa, D.P.; Freitas, R.M.; Pinto, P.L.; Moraes, J.D. Antischistosomal Activity of the Terpene Nerolidol. Molecules 2014, 19, 3793-3803.

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