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Molecules 2014, 19(3), 3793-3803; doi:10.3390/molecules19033793
Article

Antischistosomal Activity of the Terpene Nerolidol

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Received: 7 January 2014; in revised form: 13 March 2014 / Accepted: 19 March 2014 / Published: 24 March 2014
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Abstract: Schistosomiasis is a neglected tropical disease that affects hundreds of millions of people worldwide. Since the treatment of this disease currently relies on a single drug, praziquantel, new and safe schistosomicidal agents are urgently required. Nerolidol, a sesquiterpene present in the essential oils of several plants, is found in many foods and was approved by the U.S. Food and Drug Administration. In this study we analysed the in vitro antiparasitic effect of nerolidol on Schistosoma mansoni adult worms. Nerolidol at concentrations of 31.2 and 62.5 μM reduced the worm motor activity and caused the death of all male and female schistosomes, respectively. In addition, confocal laser scanning microscopy revealed morphological alterations on the tegument of worms such as disintegration, sloughing and erosion of the surface, and a correlation between viability and tegumental damage was observed. In conclusion, nerolidol may be a promising lead compound for the development of antischistosomal natural agents.
Keywords: Schistosoma; schistosomiasis; nerolidol; schistosomicial activity; natural product; neglected tropical disease; in vitro studies; confocal laser scanning microscopy Schistosoma; schistosomiasis; nerolidol; schistosomicial activity; natural product; neglected tropical disease; in vitro studies; confocal laser scanning microscopy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Silva, M.P.; Oliveira, G.L.; de Carvalho, R.B.; de Sousa, D.P.; Freitas, R.M.; Pinto, P.L.; Moraes, J.D. Antischistosomal Activity of the Terpene Nerolidol. Molecules 2014, 19, 3793-3803.

AMA Style

Silva MP, Oliveira GL, de Carvalho RB, de Sousa DP, Freitas RM, Pinto PL, Moraes JD. Antischistosomal Activity of the Terpene Nerolidol. Molecules. 2014; 19(3):3793-3803.

Chicago/Turabian Style

Silva, Marcos P.; Oliveira, George L.; de Carvalho, Rusbene B.; de Sousa, Damião P.; Freitas, Rivelilson M.; Pinto, Pedro L.; Moraes, Josué D. 2014. "Antischistosomal Activity of the Terpene Nerolidol." Molecules 19, no. 3: 3793-3803.



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