Molecules 2014, 19(3), 3247-3263; doi:10.3390/molecules19033247
Article

Omega-3 Fatty Acids Protect Renal Functions by Increasing Docosahexaenoic Acid-Derived Metabolite Levels in SHR.Cg-Leprcp/NDmcr Rats, a Metabolic Syndrome Model

1email, 1,* email, 1,2email, 1email, 1email, 3email, 3email, 4email and 1email
Received: 30 December 2013; in revised form: 7 March 2014 / Accepted: 7 March 2014 / Published: 17 March 2014
(This article belongs to the Special Issue Fatty Acids)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The omega-3 polyunsaturated fatty acids (ω-3 PUFAs) docosahexaenoic acid (DHA) and/or eicosapentaenoic acid (EPA) protect against diabetic nephropathy by inhibiting inflammation. The aim of this study was to assess the effects of highly purified DHA and EPA or EPA only administration on renal function and renal eicosanoid and docosanoid levels in an animal model of metabolic syndrome, SHR.Cg-Leprcp/NDmcr (SHRcp) rats. Male SHRcp rats were divided into 3 groups. Control (5% arabic gum), TAK-085 (300 mg/kg/day, containing 467 mg/g EPA and 365 mg/g DHA), or EPA (300 mg/kg/day) was orally administered for 20 weeks. The urinary albumin to creatinine ratio in the TAK-085-administered group was significantly lower than that in other groups. The glomerular sclerosis score in the TAK-085-administered group was significantly lower than that in the other groups. Although DHA levels were increased in total kidney fatty acids, the levels of nonesterified DHA were not significantly different among the 3 groups, whereas the levels of protectin D1, resolvin D1, and resolvin D2 were significantly increased in the TAK-085-administered group. The results show that the use of combination therapy with DHA and EPA in SHRcp rats improved or prevented renal failure associate with metabolic syndrome with decreasing triglyceride levels and increasing ω-3 PUFA lipid mediators.
Keywords: protectin; resolvin; lipidomics; diabetic nephropathy
PDF Full-text Download PDF Full-Text [647 KB, uploaded 18 June 2014 20:34 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Katakura, M.; Hashimoto, M.; Inoue, T.; Mamun, A.A.; Tanabe, Y.; Iwamoto, R.; Arita, M.; Tsuchikura, S.; Shido, O. Omega-3 Fatty Acids Protect Renal Functions by Increasing Docosahexaenoic Acid-Derived Metabolite Levels in SHR.Cg-Leprcp/NDmcr Rats, a Metabolic Syndrome Model. Molecules 2014, 19, 3247-3263.

AMA Style

Katakura M, Hashimoto M, Inoue T, Mamun AA, Tanabe Y, Iwamoto R, Arita M, Tsuchikura S, Shido O. Omega-3 Fatty Acids Protect Renal Functions by Increasing Docosahexaenoic Acid-Derived Metabolite Levels in SHR.Cg-Leprcp/NDmcr Rats, a Metabolic Syndrome Model. Molecules. 2014; 19(3):3247-3263.

Chicago/Turabian Style

Katakura, Masanori; Hashimoto, Michio; Inoue, Takayuki; Mamun, Abdullah A.; Tanabe, Yoko; Iwamoto, Ryo; Arita, Makoto; Tsuchikura, Satoru; Shido, Osamu. 2014. "Omega-3 Fatty Acids Protect Renal Functions by Increasing Docosahexaenoic Acid-Derived Metabolite Levels in SHR.Cg-Leprcp/NDmcr Rats, a Metabolic Syndrome Model." Molecules 19, no. 3: 3247-3263.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert