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Molecules 2014, 19(3), 3832-3847; doi:10.3390/molecules19033832
Article

Platinum(II) Oxalato Complexes Involving Adenosine-Based N-Donor Ligands: Synthesis, Characterization and Cytotoxicity Evaluation

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Received: 31 January 2014; in revised form: 11 March 2014 / Accepted: 21 March 2014 / Published: 24 March 2014
(This article belongs to the Section Medicinal Chemistry)
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Abstract: A one-step synthetic procedure using the reaction of potassium bis(oxalato)platinate(II) with the corresponding N6-benzyladenosine derivative (nL) provided the [Pt(ox)(nL)2]∙1.5H2O oxalato (ox) complexes 15, involving the nL molecules as monodentate coordinated N-donor ligands. The complexes were thoroughly characterized by elemental analysis, multinuclear (1H, 13C, 15N, 195Pt) and two dimensional NMR, infrared and Raman spectroscopy, and mass spectrometry, proving their composition and purity as well as coordination of nL through the N7 atom of the purine moiety. Geometry of [Pt(ox)(4FL)2] (5) was optimized at the B3LYP/LANLTZ/6-311G** level of theory. The complexes were screened for their in vitro cytotoxicity against two human cancer cell lines (HOS osteosarcoma and MCF7 breast adenocarcinoma), but they did not show any effect up to the concentration of 50.0 µM (compounds 1, 2) or 20.0 µM (compounds 35).
Keywords: platinum(II) complexes; oxalato complexes; N6-benzyladenosine derivatives; multinuclear NMR; antitumor activity; DFT calculations platinum(II) complexes; oxalato complexes; N6-benzyladenosine derivatives; multinuclear NMR; antitumor activity; DFT calculations
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Štarha, P.; Popa, I.; Trávníček, Z. Platinum(II) Oxalato Complexes Involving Adenosine-Based N-Donor Ligands: Synthesis, Characterization and Cytotoxicity Evaluation. Molecules 2014, 19, 3832-3847.

AMA Style

Štarha P, Popa I, Trávníček Z. Platinum(II) Oxalato Complexes Involving Adenosine-Based N-Donor Ligands: Synthesis, Characterization and Cytotoxicity Evaluation. Molecules. 2014; 19(3):3832-3847.

Chicago/Turabian Style

Štarha, Pavel; Popa, Igor; Trávníček, Zdeněk. 2014. "Platinum(II) Oxalato Complexes Involving Adenosine-Based N-Donor Ligands: Synthesis, Characterization and Cytotoxicity Evaluation." Molecules 19, no. 3: 3832-3847.


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