Next Article in Journal
Previous Article in Journal
Molecules 2014, 19(3), 2793-2807; doi:10.3390/molecules19032793
Article

Astragalus membranaceus Improves Exercise Performance and Ameliorates Exercise-Induced Fatigue in Trained Mice

1, 2,†, 3,†, 4,†, 4,*  and 5,*
Received: 15 February 2014; in revised form: 24 February 2014 / Accepted: 24 February 2014 / Published: 3 March 2014
(This article belongs to the Section Metabolites)
View Full-Text   |   Download PDF [8355 KB, uploaded 18 June 2014]   |   Browse Figures
Abstract: Astragalus membranaceus (AM) is a popular “Qi-tonifying” herb with a long history of use as a Traditional Chinese Medicine with multiple biological functions. However, evidence for the effects of AM on exercise performance and physical fatigue is limited. We evaluated the potential beneficial effects of AM on ergogenic and anti-fatigue functions following physiological challenge. Male ICR strain mice were randomly assigned to four groups (n = 10 per group) for treatment: (1) sedentary control and vehicle treatment (vehicle control); (2) exercise training with vehicle treatment (exercise control); and (3) exercise training with AM treatment at 0.615 g/kg/day (Ex-AM1) or (4) 3.075 g/kg/day (Ex-AM5). Both the vehicle and AM were orally administered for 6 weeks. Exercise performance and anti-fatigue function were evaluated by forelimb grip strength, exhaustive swimming time, and levels of serum lactate, ammonia, glucose, and creatine kinase after 15-min swimming exercise. Exercise training combined with AM supplementation increased endurance exercise capacity and increased hepatic and muscle glycogen content. AM reduced exercise-induced accumulation of the byproducts blood lactate and ammonia with acute exercise challenge. Moreover, we found no deleterious effects from AM treatment. Therefore, AM supplementation improved exercise performance and had anti-fatigue effects in mice. It may be an effective ergogenic aid in exercise training.
Keywords: Huangqi; exhaustion exercise; lactate; ammonia; glycogen Huangqi; exhaustion exercise; lactate; ammonia; glycogen
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Yeh, T.-S.; Chuang, H.-L.; Huang, W.-C.; Chen, Y.-M.; Huang, C.-C.; Hsu, M.-C. Astragalus membranaceus Improves Exercise Performance and Ameliorates Exercise-Induced Fatigue in Trained Mice. Molecules 2014, 19, 2793-2807.

AMA Style

Yeh T-S, Chuang H-L, Huang W-C, Chen Y-M, Huang C-C, Hsu M-C. Astragalus membranaceus Improves Exercise Performance and Ameliorates Exercise-Induced Fatigue in Trained Mice. Molecules. 2014; 19(3):2793-2807.

Chicago/Turabian Style

Yeh, Tzu-Shao; Chuang, Hsiao-Li; Huang, Wen-Ching; Chen, Yi-Ming; Huang, Chi-Chang; Hsu, Mei-Chich. 2014. "Astragalus membranaceus Improves Exercise Performance and Ameliorates Exercise-Induced Fatigue in Trained Mice." Molecules 19, no. 3: 2793-2807.



Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert