25 Results Found

Many health-promoting effects have been attributed to the intake of probiotic cells. However, it is important that probiotic cells arrive at the site of their activity in a viable state in order to exert their beneficial effects. Careful selection of...

Developing delayed-release formulations for acid-sensitive actives can be a costly and time-consuming process. However, ready-to-fill functional capsules, such as EUDRACAP^® can significantly mitigate these challenges. The in vitro performance of...

Novel calcium phosphate-based starter pellets were used to develop a biphasic-release multiple-unit pellet system (MUPS) with diclofenac sodium as a model drug in the form of hard gelatin capsules. For comparative purposes, corresponding formulations...

Currently, there is a growing need to prepare small batches of enteric capsules for individual therapy or clinical evaluation since many acidic-sensitive substances should be protected from the stomach’s acidic environment, including probiotics...

Among plant-derived polyphenols, curcumin has been recognized as a therapeutically potent nutrient presenting pleiotropic pharmacological effects on various cancers. However, the poor absorption and bioavailability of curcumin limit the use of this e...

Background: To investigate the potential synergistic effects of olive oil releasing 2-oleoylglycerol and hydrolyzed pine nut oil containing 20% pinolenic acid on GLP-1 secretion, glucose tolerance, insulin secretion and appetite in healthy individual...

Background and Objectives: The enteric form of omeprazole is one of the most commonly prescribed medications. Similarly to Europe, Kazakhstan relies on the localization of pharmaceutical drug production as one of its primary strategies to ensure that...

Objective: This study assessed the ability of capsule formulations to improve the oral delivery and retain activity of an acid-sensitive enzyme during gastrointestinal transit. Methods: The dissolution characteristics of five capsule formulations&mda...

IBD98-M is a delayed-release formulation of mesalamine (mesalazine) and SH with a potential therapeutic role in ulcerative colitis (UC). A total of 51 patients with a modified Ulcerative Colitis Disease Activity Index (UCDAI) score of ≥4 and ≤1...

Conventional gelatin capsules deliver a rapid drug release in the stomach, which is suboptimal for therapies requiring controlled and delayed release, emphasizing the need for customizable drug delivery systems for precision medicine. This study&rsqu...

Pharmaceutical technology offers several options for protecting substances from acidic environments, such as encapsulation in enteric capsules or dosage form with enteric coating. However, commercial enteric capsules do not always meet limits for pha...

Paddy field runoff containing plastic capsules that are used to coat fertilizers has been receiving increased attention. However, the behavior of these capsules, especially their degradation behavior, has not been extensively investigated. We divided...

The development of capsules with additives that can be added to polymers during extrusion processing can lead to advances in the manufacturing of textile fabrics with improved and durable properties. In this work, caffeine (CAF), which has anti-cellu...

The purpose of this study was to improve the bioavailability of carbamazepine (CBZ), a poorly water-soluble antiepileptic drug, via modified-release amorphous solid dispersions (mr-ASD) by a thin film freezing (TFF) process. Three types of CBZ-mr-ASD...

Momordica grosvenorii saponin (MGS), as a promising dietary supplement with remarkable biological properties, has poor stability under acidic conditions and thus hinders its application in functional foods. In this study, capsules of chitosan and sod...

Primula palinuri Petagna is the only Mediterranean and maritime species in the genus Primula, is endemic to coastal cliffs of southern Italy, and is classified as endangered with a decreasing population trend in the IUCN Red List. For this species, t...

Capsules with shells based on nanoparticles of different nature co-assembled at the interface of liquid phases of emulsion are promising carriers of lipophilic drugs. To obtain such capsules, theoretically using the Derjaguin–Landau–Verwe...

Polyelectrolyte microcapsules (PMCs) fabricated by layer-by-layer assembly require predictable shell stability for applications in drug delivery, biosensing, and environmental remediation. While core template type is known to influence stability, the...

In this study, the potential for correlation between disintegration and dissolution performance of enteric-coated (EC) dosage forms was investigated. Different enteric hard shell capsule formulations containing caffeine as model drug were tested for...

Seed enhancements involve post-harvest modifications that improve germination and plant performance. One form of enhancement involves coatings, which encompasses encrusting, pelleting, and film coats. These coatings may contain agrichemicals, such as...

A common problem associated with conventional gel breakers is that they can cause a premature reduction in gel viscosity at high temperatures. To address this, a urea-formaldehyde (UF) resin and sulfamic acid (SA) encapsulated polymer gel breaker was...

Cracks in reinforced concrete are preferential ingress paths for aggressive substances such as chlorides. As soon as a critical amount of chlorides has reached the steel reinforcement, corrosion will occur. Therefore, crack healing is of utmost impor...

Background/Objectives: 5-Fluorouracil (5-FU) and Irinotecan (IRT) are two of the most used chemotherapeutic agents in CRC treatment. However, achieving treatment goals has been hampered by poor drug delivery to tumor sites and associated toxicity fro...

This study used an embedding technique to prepare microcapsules with tea tree oil as the core material and a composite of β-cyclodextrin and nano-montmorillonite as the wall material. The prepared microcapsules were analyzed for their morphologi...

The betel nut is one of the most widely consumed addictive substances in the world after nicotine, ethanol, and caffeine. Arecoline is an active ingredient from the areca nut. It has many pharmacological effects and can affect the central nervous sys...