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21 Results Found

  • Article
  • Open Access
5 Citations
1,716 Views
16 Pages

Dracocephalum moldavica is widely used as an ornamental, medicine, and perfume in industry. Real-time fluorescence quantitative polymerase chain reaction (RT-qPCR) is widely and accurately utilized for gene expression evaluations. Selecting optimal r...

  • Article
  • Open Access
409 Views
34 Pages

23 December 2025

Salt–alkali stress is a major abiotic factor limiting plant growth. Dracocephalum moldavica L., an aromatic plant with medicinal and edible value, shows some potential for salt–alkali tolerance, but its response mechanisms remain unclear....

  • Article
  • Open Access
18 Citations
3,847 Views
18 Pages

7 December 2021

The development of sustainable plant production systems involves a search for different alternatives to chemical fertilizers. The aim of the present study is to compare growth and physiological effects of vermicompost on Dracocephalum moldavica plant...

  • Article
  • Open Access
49 Citations
8,043 Views
10 Pages

2 March 2016

This paper reports a novel green approach for the synthesis of silver nanoparticles (AgNPs) using aqueous seed extract of Dracocephalum moldavica (L.) under ambient conditions. Processes such as Ultraviolet-visible (UV-vis) spectrometer, field emissi...

  • Article
  • Open Access
6 Citations
2,311 Views
13 Pages

22 September 2023

This study evaluates the antioxidant properties and anti-inflammatory potential of polyphenolic acid-rich fractions of 80% methanolic extract from the hairy roots of Dracocephalum moldavica. The fractionation of the crude extract yielded the followin...

  • Article
  • Open Access
11 Citations
3,595 Views
18 Pages

Systems Pharmacology-Based Strategy to Investigate Pharmacological Mechanisms of Total Flavonoids in Dracocephalum moldavica on Chronic Heart Failure

  • Awaguli Dawuti,
  • Shuchan Sun,
  • Ranran Wang,
  • Difei Gong,
  • Tianyi Yuan,
  • Li Zhang,
  • Shiying Yang,
  • Jianguo Xing,
  • Ruifang Zheng and
  • Guanhua Du
  • + 3 authors

Heart failure (HF) is a clinical syndrome of cardiac insufficiency caused by abnormalities in cardiac structure and function that arise for various reasons, and it is the final stage of most cardiovascular diseases’ progression. Total flavonoid...

  • Communication
  • Open Access
11 Citations
3,630 Views
12 Pages

The Impact of Formulation on the Content of Phenolic Compounds in Snacks Enriched with Dracocephalum moldavica L. Seeds: Introduction to Receiving a New Functional Food Product

  • Tomasz Oniszczuk,
  • Kamila Kasprzak-Drozd,
  • Marta Olech,
  • Agnieszka Wójtowicz,
  • Renata Nowak,
  • Robert Rusinek,
  • Jarosław Szponar,
  • Maciej Combrzyński and
  • Anna Oniszczuk

25 February 2021

A new type of multigrain snack has been designed containing varied additions of Moldavian dragonhead (Dracocephalum moldavica L.) seeds. The antioxidant properties and the general health benefits of this plant material have already been widely acknow...

  • Article
  • Open Access
19 Citations
4,053 Views
12 Pages

Dracocephalum moldavica Ethanol Extract Suppresses LPS-Induced Inflammatory Responses through Inhibition of the JNK/ERK/NF-κB Signaling Pathway and IL-6 Production in RAW 264.7 Macrophages and in Endotoxic-Treated Mice

  • Kyeong-Min Kim,
  • So-Yeon Kim,
  • Tamanna Jahan Mony,
  • Ho Jung Bae,
  • Sang-Deok Han,
  • Eun-Seok Lee,
  • Seung-Hyuk Choi,
  • Sun Hee Hong,
  • Sang-Deok Lee and
  • Se Jin Park

16 December 2021

The excessive synthesis of interleukin-6 (IL-6) is related to cytokine storm in COVID-19 patients. Moreover, blocking IL-6 has been suggested as a treatment strategy for inflammatory diseases such as sepsis. Sepsis is a severe systemic inflammatory r...

  • Article
  • Open Access
13 Citations
2,996 Views
18 Pages

Evaluation of the Cytotoxic, Antioxidative and Antimicrobial Effects of Dracocephalum moldavica L. Cultivars

  • Ștefania Simea,
  • Irina Ielciu,
  • Daniela Hanganu,
  • Mihaela Niculae,
  • Emoke Pall,
  • Ramona Flavia Burtescu,
  • Neli-Kinga Olah,
  • Mihai Cenariu,
  • Ilioara Oniga and
  • Marcel Duda
  • + 1 author

7 February 2023

The aim of the present study was to correlate the antioxidant, antimicrobial, and cytotoxic activities of hydroalcoholic extracts obtained from the aerial parts of three Dracocephalum moldavica L. cultivars with their polyphenolic compositions. The p...

  • Article
  • Open Access
54 Citations
5,073 Views
16 Pages

Chemical Composition, Antioxidant, and Antimicrobial Activity of Dracocephalum moldavica L. Essential Oil and Hydrolate

  • Milica Aćimović,
  • Olja Šovljanski,
  • Vanja Šeregelj,
  • Lato Pezo,
  • Valtcho D. Zheljazkov,
  • Jovana Ljujić,
  • Ana Tomić,
  • Gordana Ćetković,
  • Jasna Čanadanović-Brunet and
  • Ljubodrag Vujisić
  • + 1 author

31 March 2022

Steam distillation was used for the isolation of Dracocephalum moldavica L. (Moldavian dragonhead) essential oil (DMEO). This aromatic herbaceous plant is widespread across the Northern Hemisphere regions and has been utilized in health-improving stu...

  • Article
  • Open Access
2 Citations
2,704 Views
18 Pages

Does the Floral Nectary in Dracocephalum moldavica L. Produce Nectar and Essential Oil? Structure and Histochemistry of the Nectary

  • Agata Konarska,
  • Elżbieta Weryszko-Chmielewska,
  • Marta Dmitruk,
  • Aneta Sulborska-Różycka and
  • Krystyna Piotrowska-Weryszko

11 November 2022

Dracocephalum moldavica is an aromatic plant with a lemon scent and versatile use. Its flowers produce large amounts of nectar, which is collected by bees and bumblebees. The aim of the study was to investigate the structure of the floral nectary in...

  • Feature Paper
  • Article
  • Open Access
15 Citations
4,145 Views
17 Pages

Drying Characteristics of Dracocephalum moldavica Leaves: Drying Kinetics and Physicochemical Properties

  • Stanisław Rudy,
  • Dariusz Dziki,
  • Beata Biernacka,
  • Andrzej Krzykowski,
  • Mariusz Rudy,
  • Urszula Gawlik-Dziki and
  • Magdalena Kachel

26 April 2020

The aim of the study was to determine the effect of the method and temperature of the sublimation, vacuum and convective drying process on the kinetics of dehydration of the Moldovan dragonhead leaves, as well as on the physical and chemical properti...

  • Article
  • Open Access
4 Citations
1,360 Views
13 Pages

Convection and Microwave–Convection Drying of Moldavian Dragonhead (Dracocephalum moldavica L.) Leaves

  • Ewa Gondek,
  • Anna Kamińska-Dwórznicka,
  • Sławomir Kocira,
  • Tomasz Oniszczuk,
  • Michał Bialik and
  • Mateusz Stasiak

10 December 2024

Moldavian dragonhead leaves are a valuable waste product from the production of seed oil, from a nutritional point of view. It has been shown that dried leaves can be used for the production of functional foods. Despite the wide possibilities of usin...

  • Article
  • Open Access
8 Citations
3,304 Views
16 Pages

Growth Characteristics of Dracocephalum moldavica L. in Relation to Density for Sustainable Cropping Technology Development

  • Cristina Moldovan,
  • Sorina Nițu (Năstase),
  • Manuela Hermeziu,
  • Roxana Vidican,
  • Mignon Sandor,
  • Ștefania Gâdea,
  • Adriana David,
  • Valentina Ancuța Stoian,
  • Sorin Daniel Vâtcă and
  • Vlad Stoian

Medicinal and aromatic plants hold a high share of interest in Romania. To offset the harvesting of spontaneous flora and ensure the sustainable conservation of natural resources, the cropping of highly valuable plants of interest represents a priori...

  • Article
  • Open Access
14 Citations
3,311 Views
10 Pages

17 November 2022

Phenolic plant constituents are well known for their health-promoting and cancer chemopreventive properties, and products containing such constituents are therefore readily consumed. In the present work, we isolated 13 phenolic constituents of four d...

  • Article
  • Open Access
42 Citations
5,757 Views
16 Pages

Use of FTIR Spectroscopy and Chemometrics with Respect to Storage Conditions of Moldavian Dragonhead Oil

  • Arkadiusz Matwijczuk,
  • Tomasz Oniszczuk,
  • Alicja Matwijczuk,
  • Edyta Chruściel,
  • Anna Kocira,
  • Agnieszka Niemczynowicz,
  • Agnieszka Wójtowicz,
  • Maciej Combrzyński and
  • Dariusz Wiącek

14 November 2019

Oils often have similar properties and can be difficult to identify based on color, smell or taste alone. The present paper suggests the use of Fourier-transform infrared spectroscopy (FTIR) in combination with chemometric methods to explore similari...

  • Article
  • Open Access
14 Citations
3,322 Views
18 Pages

3 February 2022

Dracocephalum heterophyllum (Lamiaceae: tribe Mentheae) is an annual aromatic herb native to East Asia with a long record of human uses, including medicinal, alimentary, and ornamental values. However, no information is available about its molecular...

  • Article
  • Open Access
54 Citations
10,955 Views
23 Pages

23 January 2020

Medicinal and aromatic plants have the ability to transmit volatile allelochemicals and affect their surrounding organisms. In this regard, their interaction should also be considered. The inhibitory effects of 112 essential oils on lettuce seed and...

  • Review
  • Open Access
28 Citations
5,768 Views
20 Pages

Tilianin: A Potential Natural Lead Molecule for New Drug Design and Development for the Treatment of Cardiovascular Disorders

  • Farrah Syazana Khattulanuar,
  • Mahendran Sekar,
  • Shivkanya Fuloria,
  • Siew Hua Gan,
  • Nur Najihah Izzati Mat Rani,
  • Subban Ravi,
  • Kumarappan Chidambaram,
  • M. Yasmin Begum,
  • Abul Kalam Azad and
  • Neeraj Kumar Fuloria
  • + 7 authors

20 January 2022

Cardiovascular disorders (CVDs) are the leading risk factor for death worldwide, and research into the processes and treatment regimens has received a lot of attention. Tilianin is a flavonoid glycoside that can be found in a wide range of medicinal...

  • Article
  • Open Access
372 Views
19 Pages

Tilianin Attenuates Myocardial Ischemia–Reperfusion Injury by Targeting RIP3-Mediated Necroptosis

  • Ruifang Zheng,
  • Jie Yang,
  • Xuemeng Wang,
  • Yuanyuan Jin,
  • Yue Wang,
  • Wenling Su,
  • Naihong Chen,
  • Shifeng Chu,
  • Jianguo Xing and
  • Ming Xu

31 December 2025

Background/Objectives: Necroptosis is a critical process in the pathogenesis of myocardial ischemia–reperfusion injury (MIRI). Tilianin (Til), a natural flavonoid glycoside derived from Dracocephalum moldavica L., exhibits significant therapeut...