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Psychiatry International
Special Issues
Cognitive Functioning Across Severe Psychiatric Disorders: From Research to Clinical...
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Cognitive Functioning Across Severe Psychiatric Disorders: From Research to Clinical Practice

A special issue of Psychiatry International (ISSN 2673-5318). This special issue belongs to the section "Clinical Neurobiology, Precision Psychiatry and Artificial Intelligence".

Deadline for manuscript submissions: 31 December 2026 | Viewed by 2221

Special Issue Editors

Dr. Thiago P. Fernandes

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Guest Editor
Department of Psychology, Universidade Federal da Paraíba, Joao Pessoa 58051-900, Paraíba, Brazil
Interests: neuroscience; psychophysiology; visual perception; visual neuroscience; electrophysiology
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Natanael Antonio dos Santos

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Guest Editor
Department of Psychology, Federal University of Paraíba, João Pessoa, Brazil
Interests: neuroscience; cognitive neuroscience; electrophysiology; psychophysiology; psycho-pharmacology
Dr. Irina Ivanovna Shoshina

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Guest Editor
Department of Biological Sciences, St Petersburg State University, Saint-Petersburg, Russia
Interests: physiology; psychopathology; neuroscience; biological sciences; neuropsychiatry
Dr. Milena Edite Casé De Oliveira

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Guest Editor
Department of Psychology, Federal University of Paraiba, Joao Pessoa, Brazil
Interests: neuroscience; oncology; breast cancer; chemotherapy; cognition; psychology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to announce the launch of a new Special Issue of Psychiatry International, titled “Cognitive Functioning Across Severe Psychiatric Disorders: From Research to Clinical Practice.” This Special Issue invites contributions from our esteemed Editorial Board Members and leading scholars, focusing on studies that advance understanding of cognitive functioning in severe psychiatric conditions and its relevance for clinical practice.

Cognitive impairments are central to daily functioning and quality of life, yet they remain under-recognised in many psychiatric disorders. Research in this area can shed light on underlying mechanisms, support more accurate assessment and prognosis, and inform interventions that enhance functional outcomes.

This Special Issue will supplement existing literature by bringing together findings across diagnostic categories and integrating diverse methodological approaches, providing a comprehensive perspective to guide future research and inform clinical practice. The Special Issue will focus on high-burden and complex mental disorders, encompassing major depressive disorder, bipolar disorder, schizophrenia spectrum disorders, obsessive compulsive spectrum disorders, and anxiety disorders.

We welcome submissions covering all aspects of cognition, including neurocognition, social cognition, and cognitive interventions, as well as studies that link rigorous research with meaningful clinical insights. Accepted papers will be compiled into a printed volume and actively promoted. We look forward to your contributions to this initiative, which seeks to advance mental health care through innovation and interdisciplinary collaboration.

Dr. Thiago P Fernandes
Prof. Dr. Natanael Antonio dos Santos
Dr. Irina Ivanovna Shoshina
Dr. Milena Oliveira
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Psychiatry International is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cognitive functioning
  • neurocognition
  • cognitive impairment
  • severe mental illness
  • psychiatric disorders
  • psychosis
  • depression
  • cognitive interventions
  • functional outcomes

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Review

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21 pages, 2441 KB  
Review
The Neurocognitive Basis of Oral Health Decline in Schizophrenia: From Functional Impairment to Prevention
by Simona Manuela Bida, Florin Razvan Curca, Oana Maria Butnaru and Roxana Chirita
Psychiatry Int. 2026, 7(1), 31; https://doi.org/10.3390/psychiatryint7010031 - 3 Feb 2026
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Abstract
Background: Schizophrenia is strongly associated with severe oral health deterioration, driven by cognitive deficits, behavioral dysfunction, and medication-related biological changes. Objective: To examine how neurocognitive dysfunction in schizophrenia, particularly cognitive deficits, is associated with poorer oral hygiene control, motivation, and self-regulation, contributes to [...] Read more.
Background: Schizophrenia is strongly associated with severe oral health deterioration, driven by cognitive deficits, behavioral dysfunction, and medication-related biological changes. Objective: To examine how neurocognitive dysfunction in schizophrenia, particularly cognitive deficits, is associated with poorer oral hygiene control, motivation, and self-regulation, contributes to oral health decline by disrupting everyday oral hygiene behaviors and dental care engagement, and to discuss the implications of this framework for interdisciplinary prevention strategies. Methods: This manuscript follows a narrative review design aimed at conceptually integrating evidence on neurocognitive mechanisms underlying oral health decline in schizophrenia. To identify relevant literature, a targeted search of PubMed/MEDLINE, Scopus, and Web of Science was conducted, covering publications from 2000 to 2025. The search strategy was used to support thematic exploration and conceptual synthesis, rather than to perform a systematic study selection or quantitative evidence aggregation. This narrative review summarizes findings from 90 peer-reviewed studies selected from the available literature. Results: Executive dysfunction, attentional deficits, and low motivation impair routine oral hygiene and delay dental care-seeking. Antipsychotic-induced xerostomia, metabolic disturbances, oxidative stress, immune dysregulation, and oral microbiome dysbiosis accelerate periodontal breakdown and caries progression. These interacting processes generate a self-reinforcing cycle of inflammation, tissue destruction, and treatment avoidance. Epidemiological data show markedly elevated DMFT/DMFS indices and up to a three-fold higher risk of edentulism compared with the general population. Emerging evidence suggests that integrated psychiatric–dental care models may be associated with improvements in oral health and care engagement, although current findings are largely preliminary and based on small or heterogeneous study populations, including related neurocognitive disorders. Conclusions: Unlike existing epidemiological syntheses, this review highlights oral health deterioration in schizophrenia as a functionally mediated consequence of neurocognitive impairment, underscoring the need for preventive approaches aligned with patients’ cognitive and motivational capacities. Full article
(This article belongs to the Special Issue Cognitive Functioning Across Severe Psychiatric Disorders: From Research to Clinical Practice)
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14 pages, 1420 KB  
Systematic Review
Comparative Efficacy of rTMS and Psychosurgery in Severe OCD: A Systematic Review and Meta-Analysis of Responder Rates
by Andrés Vega-Rosas, Naomi G. Santos-Jacinto, Sergio Martinez-del Angel and Andrea Granados-Juárez
Psychiatry Int. 2026, 7(3), 96; https://doi.org/10.3390/psychiatryint7030096 - 3 May 2026
Viewed by 743
Abstract
Background: Severe, treatment-resistant Obsessive–Compulsive Disorder (OCD) remains a major clinical challenge. When conventional pharmacological and psychotherapeutic strategies fail, neuromodulatory interventions such as repetitive transcranial magnetic stimulation (rTMS) and psychosurgical approaches are increasingly considered. Although both modalities target nodes within the cortico-striato-thalamo-cortical (CSTC) circuit, [...] Read more.
Background: Severe, treatment-resistant Obsessive–Compulsive Disorder (OCD) remains a major clinical challenge. When conventional pharmacological and psychotherapeutic strategies fail, neuromodulatory interventions such as repetitive transcranial magnetic stimulation (rTMS) and psychosurgical approaches are increasingly considered. Although both modalities target nodes within the cortico-striato-thalamo-cortical (CSTC) circuit, their relative effectiveness has not been examined within a unified analytical framework. Objective: We aimed to compare responder rates between rTMS and psychosurgical interventions in adults with treatment-resistant OCD through a systematic review and meta-analysis. Methods: A PRISMA-guided search of PubMed and Scopus (2015–2025) identified clinical studies reporting treatment response. Pooled responder rates were estimated separately for each modality using random-effects models. Between-study heterogeneity and publication bias were systematically assessed. Results: Fourteen studies met inclusion criteria, including 10 rTMS studies (416 participants) and four lesion-based psychosurgical studies (142 participants). Both modalities demonstrated clinically meaningful responder rates. Pooled analyses suggested higher responder proportions in psychosurgical cohorts (RR = 3.06, 95% CI 1.43–6.54); however, this finding was accompanied by substantial heterogeneity (I2 = 63%) and signals of publication bias. Follow-up duration differed markedly between modalities (mean 2.4 months for rTMS vs. 33.0 months for psychosurgery), reflecting fundamentally different study designs and outcome assessment timepoints. Conclusions: Differences in pooled responder rates should be interpreted as exploratory rather than as evidence of comparative efficacy. The lack of a shared comparator, differences in patient selection, and large discrepancies in follow-up limit direct comparisons between modalities. These findings support a stepped-care framework for neuromodulation in treatment-resistant OCD and highlight the need for methodologically harmonized studies to better define the role of each intervention across distinct clinical profiles of treatment resistance. Full article
(This article belongs to the Special Issue Cognitive Functioning Across Severe Psychiatric Disorders: From Research to Clinical Practice)
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